Atypical Chronic Myeloid Leukemia, BCR-ABL1- (ACML)
Overview
Atypical Chronic Myeloid Leukemia, BCR-ABL1-negative (ACML) is a rare myelodysplastic/myeloproliferative neoplasm under the MDS/MPN parent in OncoTree. It resembles CML morphologically but lacks the BCR-ABL1 fusion. CALR mutations have been rarely identified in ACML.
Cohorts in the corpus
- mpn_cimr_2013 — 1 ACML patient included in a 1,345-case hematologic cancer follow-up screen for CALR mutations. PMID:24325359
Recurrent alterations
- In a follow-up Sanger sequencing screen of 1,345 hematologic cancers, only 1/29 ACML cases carried a CALR exon 9 frameshift indel, confirming that CALR mutations are rare outside the BCR-ABL1-negative MPN spectrum. PMID:24325359
Subtypes
- No molecular subtypes defined in the current corpus.
Therapeutic landscape
- No ACML-specific drug data in the current corpus.
Sources
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