Papers

Title Year Journal Cancer types Genes
Radiation Oncology-Biology Integration Network (ROBIN): Bridging the gap between biological research and clinical practice 2026 Clin Cancer Res PRAD, READ, BLCA, HNSC, CESC, PAAD, DMG, NBL MYC, TP53, MDM2, CD274, PDCD1
Somatic mutations in STAG2 are associated with separated megakaryocyte nuclear lobes in myelodysplastic syndromes 2025 Blood Advances MDS STAG2, ASXL1, SF3B1, SRSF2, RUNX1, SETBP1, TP53, NRAS
ARID1A Governs Genomic Stability and Proliferation in SCLC via c-MYC/PARP1 Suppression Driving Vulnerability to BET Inhibitors 2025 Research SCLC ARID1A, MYC, PARP1, RAD51, CHEK1, ARID1B, BRD4, AKT1, PIK3CA
AI-driven multimodal algorithm predicts immunotherapy and targeted therapy outcomes in clear cell renal cell carcinoma 2025 Cell Reports Medicine CCRCC BAP1, SETD2, MTOR, PBRM1, KDM5C, NF2, CD274, PDCD1
Distinct and convergent effects of SF3B1 mutations in human breast cancer 2025 Proceedings of the National Academy of Sciences BRCA SF3B1, TP53, PIK3CA, MKI67, MYC, DLST, GCC2, TMEM14C, ENOSF1
Novel Strategy for Acquiring Metabolically-Tagged Nascent Extracellular Vesicles: Implications for Identifying Surface Protein Markers of Extracellular Vesicles From Neuroblastoma Cells Cultured With Native Serum 2025 Journal of Extracellular Vesicles NBL GJC1, MYCN
Hepatitis B virus integration and hepatocarcinogenesis 2025 Liver Research HCC TERT, KMT2D, CCNE1, MYC, TP53, RB1, CTNNB1, GSK3B, MTOR, DNMT3A, CASP1
HIFα isoform specific activities drive cell-type specificity of VHL-associated oncogenesis 2025 Nature Communications CCRCC VHL, HIF1A, EPAS1, PAX8, HNF4A, HNF1B, FOXA2, MKI67, CCND1, TP53, RB1
Genomic and transcriptomic landscapes of metastatic neuroendocrine neoplasms from distinct primary sites and their clinical implications 2025 Scientific Reports PANET, PANEC, LNET, LUNE, MTNN, SBWDNET, HGONEC, MNET, NETNOS MEN1, DAXX, ATRX, RB1, TP53, RET, MYC, MYCN, KRAS, SMAD4, CDK8, FLT1, NTHL1, MSH6, MLH1, MSH3, CDKN2A, CDKN2B, TSC1, TMEM71, BRIP1, TOP2A, MGMT, CD274, PDCD1, DLL3, SSTR2, RICTOR, FGFR3, PIK3R2, MET, PDGFRA, PDGFRB
Molecular Profiling of Sinonasal Adenoid Cystic Carcinoma: Canonical and Noncanonical Gene Fusions and Mutation 2025 American Journal of Surgical Pathology ACYC MYB, MYBL1, NFIB, EWSR1, ACTB, ACTN4, ESRRG, DNM3, BCOR, NOTCH1, NOTCH2, NOTCH3, EP300, SMARCA4, RUNX1, KDM6A, SPEN, RIT1, MGA, RB1, PHF6, PTEN, CREBBP, DDX41, CHD2, ROS1, TAF1, CCND1, NF1, PALB2, ACVR1B, ARID1A, ARID1B, PPM1D, LZTR1, GEN1, PDGFRA, PBRM1, BRAF, FAT1, RET
Exploring the Diagnostic and Predictive Value of Oral Microbiome in Esophageal Cancer: A Systematic Review and Meta-Analysis 2025 International Journal of Molecular Sciences ESCC, ESCA TP53, RB1, CDKN2A, PIK3CA, NOTCH1, NFE2L2
Divergent Morphologies and Common Signaling Features of Active and Inactive Oncogenic RHOA Mutants in Yeast 2025 Cells AITL, ATLL, DSTAD, BL, PTCL RHOA
Familial Non-Hereditary Gastric Cancer: Diagnosis, Management, Molecular Characteristics and Future Perspective 2025 Cancers STAD CDH1, CTNNA1, CTNND1, TP53, RHOA, MLH1, MSH2, MSH6, PMS2, EPCAM, APC, BMPR1A, SMAD4, MUTYH, STK11, BRCA1, BRCA2, PALB2, ATM, BRIP1, DOT1L, INSR, FBXO24, FHIT, PSCA, PLCE1, PRKAA1, MUC1, XRCC1, GSTM1, IL1B, TNF, IL10, RASSF1, LOX, KDM4B, PTGS2, CDKN1A, YAP1
Novel Therapeutic Development for Nasopharyngeal Carcinoma 2025 Current Oncology NPC, HNSC EGFR, ERBB3, MET, AXL, KDR, VEGFA, PDGFRB, KIT, RET, FLT3, TEK, CDK4, CDK6, PARP1, XIAP, BIRC2, BIRC3, CD70, CD276, EPCAM, MUC1, PDCD1, CD274, CTLA4, LAG3, HAVCR2, BTLA, TNFRSF4, TNFRSF9, ADORA2A, IKZF2, FOXP3, PTCH1, RASSF1, BBC3, BCL2L11
Matrix stiffness induced gallbladder fibroblasts activation and paracrine SEMA7A promotes gallbladder cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating AKT/p300 signalling 2025 Biology Direct GBC SEMA7A, ITGB1, PLXNC1, EP300, AKT1, YAP1, WWTR1, TEAD1, ACTA2, CCN2, COL1A1, COL1A2, COL4A1, COL4A2, COL8A1, FN1, MFAP5, PDGFRA, TGFBR1, TGFBR2, CDH1, VIM, EPCAM, CD44, ALDH1A1, SNAI1, ZEB1, EGFR, ERBB2, ERBB3, ERBB4
EWS::FLI1 expression in human embryonic mesenchymal stem cells leads to transcriptional reprograming, defective DNA damage repair and Ewing sarcoma 2025 Nature Communications ES EWSR1, FLI1, BRCA1, ATM, ATR, PRKDC, PRKCB, CD99, EZH2, IGF1, NGFR, PADI2, DKK2, NR0B1, UCP2, BCL11B, ITM2A, RNF2, TP53, CDKN1A, RB1
Chronic Liver Disease Associated Cholangiocarcinoma: Genomic Insights and Precision Therapeutic Strategies 2025 Cancers IHCH, EHCH, CHOL, HCC KRAS, TP53, ARID1A, CDKN2A, CDKN2B, EGFR, PIK3CA, BRAF, BRCA1, BRCA2, SMAD4, IDH1, IDH2, FGFR2, FGFR1, ERBB2, BAP1, PTEN, TERT, MET, ALKBH5, FAT2, NTRK1, NTRK2, NTRK3, DDX1, ALDH1A1, TGFBR2, FBXW7, MYC
Targeting the gut-liver axis in cholangiocarcinoma: mechanisms, therapeutic advances, and future directions 2025 Frontiers in Oncology CHOL, IHCH, EHCH, PHCH, HCC, GBC NR1H4, GPBAR1, S1PR2, IDH1, IDH2, FGFR2, EGFR, KRAS, TP53, METTL3, STAT3, BCL2L1, PTGS2, CXCL16, CXCL1, ABCB11, HNF4A, CYP7A1, FGF19, SLCO1B3, CEACAM1, TGFB1, PDCD1
SF3B1 mutation accelerates the development of CLL via activation of the mTOR pathway 2025 JCI Insight CLLSLL SF3B1, NFATC1, MYC, MTOR, DLEU1, DLEU2, MIR15A, ATM, ZAP70, CD5, BRD9, PPP2R5A, AKT1
Rat somatic genome editing enables ER+ breast cancer modeling 2025 bioRxiv BRCA, IDC, DCIS, MBC TP53, PIK3CA, NF1, KRAS, HRAS, ESR1, PGR
Mutation burden of narrowband ultraviolet B phototherapy (NB-UVB) in human skin: relevance to NB-UVB lifetime exposures and skin cancer surveillance 2025 British Journal of Dermatology CSCC, BCC, SKIN
A profile of lung cancer in the young population with a highlight on the Indian perspective 2025 Frontiers in Oncology NSCLC, LUAD EGFR, ALK, ROS1, KRAS, BRAF, MET, ERBB2, RET, NTRK1, NTRK2, NTRK3, TP53, BRCA1, BRCA2, ATM, CHEK2, BAP1, FANCA, FANCI, FANCM, LZTR1, XRCC3, EML4, ERC1
Targeting the ATM-TRMT10A-BRCA1 axis confers synthetic lethality to PARP inhibition in metastatic castration-resistant prostate cancer 2025 Science Advances PRAD TRMT10A, USP10, BRCA1, BRCA2, ATM, ATR, RAD51, PALB2, PARP1, PARP2
EWSR1::BEND2 fusion sarcoma of the urinary bladder – a case report and review of literature 2025 Diagnostic Pathology BLCA, ES, ASTB EWSR1, BEND2, PTEN, MN1, FLI1, NFATC2, PATZ1, POU2AF3, CIC, BCOR, FUS
Genomic landscape of endometrial polyps 2025 Genome Medicine UCEC, ULM HMGA1, HMGA2, UBE2A, PLAG1, KRAS, PIK3CA, PIK3R1, PTEN, ERBB2, PPP2R1A, FBXW7, ARHGAP35, PIEZO2, LRMDA, RAD51B, TRAF3IP2, ZMAT3, C19ORF38, MED12, JAZF1, MATR3
Combined SNPs sequencing and allele specific proteomics capture reveal functional causality underpinning the 2p25 prostate cancer susceptibility locus 2025 Nature Communications PRAD NOL10, USF1, TBX3, TFAP4, TMPRSS2, ERG, HNF1B, APOBEC3A, APOBEC3B, STK11
Germline variants observed in pediatric cancer patients related to hereditary breast and ovarian cancer in adults 2025 International Journal of Cancer BLLNOS, TLL, AML, MBL, LCH, RMS, OS, LIHB TP53, CHEK2, ATM, NF1, NBN, BRIP1, BRCA1, BRCA2, BLM, FANCC, FANCM, MSH2, STK11
CHEK1 is a synthetic lethal interactor of FBXO7 in colonic epithelial cells 2025 Molecular Therapy: Oncology COADREAD FBXO7, CHEK1, CHEK2, SOD1, BRCA1, BRCA2, PARP1, ATM, CDK2, SKP1, CUL1, RBX1, APC, KRAS, TP53
A deep multiple instance learning framework improves microsatellite instability detection from tumor next generation sequencing 2025 Nature Communications COAD, UCEC, EGC, BLCA, PRAD, CUP, SBC MLH1, MSH2, MSH6, PMS2, POLE
Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival 2025 Nature Medicine PAAD KRAS, BRAF, NRAS, NF1, NTRK1, NTRK3, FGFR2, ERBB2, MAP2K1, ROS1, MET, RAF1, TP53, CDKN2A, CDKN2B, SMAD4, BRCA1, BRCA2, ATM, PALB2, CHEK2, MLH1, MSH2, MSH6, PMS2, GNAS, PIK3CA, SMARCB1, FOXP1, CREBBP, ARID1A, RNF43, AKT2, RB1, BAP1, MYC
Somatic mutations distinguish melanocyte subpopulations in human skin 2025 bioRxiv SKIN, MEL HMOX1, ABCC2, MC1R, HERC2, LIPA, HLA-DPA1, VCAN, FBN1, PALLD, ITM2A, TAGLN, MYL9, MYLK, SGCE, HACD1, SEMA3C, TCF4, DAAM2, RGMB, NTNG1, PMEL, TYRP1, MLANA, MITF, AXL, KRT14, KRT17, KRT5, LUM, COL1A1, S100A4
Circulating Tumor DNA and Response to Cisplatin-based Chemotherapy in Patients with Metastatic Urothelial Carcinoma Enrolled in CALGB 90601 (Alliance) 2025 European Urology Open Science BLCA TERT, PIK3CA, ERBB2, ERCC2, FGFR3, ATM, BRCA1, BRCA2, KDM6A, RB1, TSC1, BRAF, KRAS, MDM2
A platform-independent AI tumor lineage and site (ATLAS) classifier 2024 Communications Biology CUP, NSCLC, LUAD, LUSC, SCLC, PRAD, PRNE, BRCA, MEL, PLMESO
Clinical and molecular characteristics of early-onset vs average-onset esophagogastric cancer 2024 JNCI: Journal of the National Cancer Institute EGC, STAD, ESCA, GEJ ERBB2, CDKN2A, KRAS, CCNE1, PIK3CA, CDH1, ARID1A
Tumor Volume Growth Rates and Doubling Times during Active Surveillance of IDH-mutant Low-Grade Glioma 2024 Clinical Cancer Research DIFG, ASTR, ODG IDH1, IDH2, CDKN2A, CDKN2B, TERT, CIC, FUBP1, TP53, ATRX, MYCN, CDK4, PDGFRA, PIK3R1, PIK3CA
The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen 2024 Cancer Research DIFG, GB, ASTR, ODG IDH1, IDH2, HOXD13, CDKN2A, MGMT, MYB, RSPO4, CENPF, PCNA, HOXA7, MSH6, NEUROD1
High-risk and silent clonal hematopoietic genotypes in patients with nonhematologic cancer 2024 Blood Advances JAK2, RUNX1, XPO1, DNMT3A, TET2, ASXL1, TP53
RADCURE: An open-source head and neck cancer CT dataset for clinical radiation therapy insights 2024 Medical Physics HNSC
The genomic and evolutionary landscapes of anaplastic thyroid carcinoma 2024 Cell Reports THAP, THPA TP53, BRAF, NRAS, PIK3CA, USH2A, CDKN2A, BRCA1, BRCA2, RB1, ATM, ATR, NF1, EIF1AX, TERT, TET1, MET, NOTCH1, FAT1, SPEN, LRP1, CDK7, FLT3, FGF9, HMCN1, HSPG2, RECQL4, FANCF, VGLL3
Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma 2024 Clinical Cancer Research LMS, ULMS TP53, RB1, ATRX, PTEN, CDKN2A, MED12
Integrative Molecular Analyses of the MD Anderson Prostate Cancer Patient-derived Xenograft (MDA PCa PDX) Series 2024 Clinical Cancer Research PRAD, PRNE AR, PTEN, RB1, TP53, CDK12, TMPRSS2, ERG, ETV4, ETV1, FGFR1, SPOP, FOXA1, NRAS, SPEN, RNF43, KMT2D, AURKA, MYCN, ATM, BRCA1, BRCA2, CHEK2, KDM6A
Validation of LymphGen classification on a 400-gene clinical next-generation sequencing panel in diffuse large B-cell lymphoma: real-world experience from a cancer center 2024 Haematologica DLBCLNOS BCL2, BCL6, MYC, TP53, MYD88, CD79B
Diffuse pleural mesotheliomas with genomic near-haploidization: a newly recognized subset with distinct clinical, histologic, and molecular features 2024 Clinical Cancer Research PLMESO SETDB1, TP53, NF2, BAP1, CDKN2A, CDKN2B, MLH1
Nivolumab for mismatch-repair-deficient or hypermutated gynecologic cancers: a phase 2 trial with biomarker analyses 2024 Nature Medicine UCEC, OVT MLH1, MSH2, MSH6, PMS2, PTEN, PIK3CA, ARID1A, JAK1, CTNNB1, MEGF8, SETD1B, PTCH1, KRAS, TP53, B2M, POLE, PBRM1, ARID2
Genome-wide loss of heterozygosity predicts aggressive, treatment-refractory behavior in pituitary neuroendocrine tumors 2024 Acta Neuropathologica PTAD TP53, ATRX, DAXX, SF3B1, USP8, MSH2, MSH6, MLH1, GNAS, TSC2, TERT, CCND3, CDKN2A, CDKN2B
Intensity-Modulated Reirradiation Therapy With Nivolumab in Recurrent or Second Primary Head and Neck Squamous Cell Carcinoma: A Nonrandomized Controlled Trial 2024 JAMA Oncology HNSC CD274, PDCD1, MKI67, CD4, CD8A, FOXP3
A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: the Hidden-Genome Classifier 2024 Clinical Cancer Research IHCH, EHCH, GBC, HCC KRAS, SMAD4, CDKN2A, TERT, FGFR2, IDH1
Molecular effects of indoor tanning 2024 bioRxiv MEL NF1, BRAF, CDKN2A, RAC1, PPP6C, ARID2, RB1
Tumor-agnostic genomic and clinical analysis of BRAF fusions identify actionable targets 2024 Clinical Cancer Research ASTR, LUAD, MEL, COAD, PAAD, PRAD, THPA, BLCA, ECD BRAF, EGFR, TP53, CDKN2A, CDKN2B, TERT, RNF43, KMT2D, MSH3, ARID1A, KIAA1549, SND1, AGK, TRIM24, KRAS, HRAS, NRAS, RAF1, MAPK1, NTRK1, FGFR3, ALK, INPPL1
Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer 2024 Clinical Cancer Research PRAD MSH2, MSH6, MLH1, PMS2, POLE, JAK1, BRCA2, BRCA1, ERG, TMPRSS2, ASXL1, MSH3
A Phase II study assessing Long-Term Response to Ibrutinib Monotherapy in recurrent or refractory CNS Lymphoma 2024 Clinical Cancer Research PCNSL, DLBCLNOS TBL1XR1, MYD88, CD79B, CARD11
Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma 2024 bioRxiv CSCC TP53, NOTCH1, NOTCH2, CDKN2A, TERT, ARID2, CBL, FAT1
DNA liquid biopsy-based prediction of cancer-associated venous thromboembolism 2024 Nature Medicine NSCLC, BRCA, PAAD, MEL, PRAD, BLCA KRAS, STK11, KEAP1, TP53, EGFR, PIK3CA, CDKN2A, CTNNB1, ERBB2, ARID1A, ATM, RB1, NF1, PTEN, BRAF, SMAD4, SF3B1, KDM6A
Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer 2024 Cancer Cell PAAD KRAS, TP53, CDKN2A, SMAD4, BRAF, TGFBR2, MYC
Real-world experience with circulating tumor DNA in cerebrospinal fluid from patients with central nervous system tumors 2024 Acta Neuropathologica Communications NSCLC, LUAD, BRCA, DIFG, DMG, MEL TP53, EGFR, KRAS, BRAF, PIK3CA, MET, ERBB2, ALK, RET, ROS1, STK11, KEAP1, IDH1, EML4, H3-3A, KIAA1549
The landscape of drug sensitivity and resistance in sarcoma 2024 Cell Stem Cell OS, CHDM, CHS, ES, SYNS, MPNST, RMS, LMS, MFH, EPIS, DSRCT, PECOMA, MFS, WDLS, DDCHS, ARMS, ERMS, SCSRMS, IFS, SARCNOS, FIBS, LIPO PIK3CA, MDM2, NTRK1, NTRK2, NTRK3, ETV6, FGFR1, ARID2, CRTC1, MAP3K1, EGFR, ERBB2, CDK4
Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma 2024 bioRxiv HGSOC TP53, BRCA1, BRCA2, CCNE1, HLA-A, HLA-E, STAT1, CGAS, STING1, TBK1, ISG15, IFITM1, IRF7, IRF9, TAP1, MX1, MCL1, IFNE, MYC, BANF1, KLRK1, PDCD1, LAG3, HAVCR2, CTLA4, FOXP3, CD4, CD8A, CXCL9
Automated real-world data integration improves cancer outcome prediction 2024 Nature NSCLC, LUAD, BRCA, COAD, READ, PRAD, PAAD, PAAC SETD2, TP53, PTEN, RB1, EGFR, KRAS, BRAF, ARID1A, MDM2, STK11, SMARCA4, KEAP1, CDKN2A, BRCA2, MET, ESR1, CCND1, NF1, AR, CHEK2, PPM1D, CDK12, FGF19, MYC, CIC, NKX3-1, NKX2-1, FOXA1, FGFR1, ERBB2, CCNE1, CD274
Molecular Characterization of Acquired Resistance to KRASG12C-EGFR Inhibition in Colorectal Cancer 2023 Cancer Discovery COADREAD KRAS, NRAS, BRAF, EGFR, MET, RET, MAP2K1, MYC, APC, TP53, PIK3CA, ERBB2, ERBB3, ERBB4, RAF1, NF1, FGFR2, PTEN, RB1
Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis 2023 Nature Cancer BRCA TP53, ESR1, ERBB2, PIK3CA, PTEN, RB1, KMT2C, NF1, GATA3, MYC, MDM4, FOXA1, HLA-A, B2M, JAM3, BRCA2
Expanded genetic testing of GIST patients identifies high proportion of non-syndromic patients with germline alterations 2023 npj Precision Oncology GIST KIT, PDGFRA, SDHA, SDHB, SDHC, NF1, BRAF, BRCA1, BRCA2, TP53, MLH1
Molecular Evolution of Classic Hodgkin Lymphoma Revealed Through Whole-Genome Sequencing of Hodgkin and Reed Sternberg Cells 2023 Blood Cancer Discovery CHL SOCS1, TNFAIP3, B2M, ITPKB, GNA13, STAT6, BCL7A, NFKBIE, PTPN1, TP53, XPO1, TMSB4X, IL4R
Overcoming barriers to tumor genomic profiling through direct-to-patient outreach 2023 Clinical Cancer Research LCH, ECD, OGCT, MGCT, ACYC BRAF, MAP2K1, KRAS, NRAS, CSF1R, ALK, NTRK1, PIK3CA, PTPN11, KIT, TP53, ERBB2
TP53 mutations identify high-risk events for peripheral T-cell lymphoma treated with CHOP-based chemotherapy 2023 Blood Advances PTCL, AITL, ALCL, ALCLALKP, ALCLALKN, MEITL, EATL TP53, CDKN2A, TET2, RHOA, DNMT3A, IDH2, STAT3, FAT1, TP63
Genomic Mapping of Metastatic Organotropism in Lung Adenocarcinoma 2023 Cancer Cell LUAD TP53, SMARCA4, CDKN2A, KEAP1, STK11, EGFR, KRAS, NF1, MDM2, PIK3CA, ERBB2, NKX2-1, FOXA1, MET, ARID1A, MGA
An integrated tumor, immune and microbiome atlas of colon cancer 2023 Nature Medicine COAD IFNG, TBX21, CD8A, CD8B, IL12B, STAT1, IRF1, CCL5, CXCL9, CXCL10, GNLY, PRF1, GZMA, GZMB, GZMH, CD274, CTLA4, FOXP3, IDO1, PDCD1
Extremity Rhabdomyosarcoma: An Integrated Clinicopathologic and Genomic Study to Improve Risk Stratification 2023 JCO Precision Oncology RMS, ARMS, ERMS, SCRMS FOXO1, PAX3, PAX7, MYOD1, MED12, CDK4, CDKN2A
Distinct genomic landscapes in radiation-associated angiosarcoma compared with other radiation-associated sarcoma histologies 2023 J Pathol ANGS, MPNST, MFH, OS MYC, FLT4, CRKL, HRAS, KMT2D, TP53, KDR, ATM, ATRX, CDKN2A, CDKN2B, NF1, SUZ12, TEK, PTPRD, RB1, PTEN, FGFR1, PTPRT, NOTCH3, KIT, PDGFRA, PTPRB, PLCG1
Multi-institutional Prognostic Modeling in Head and Neck Cancer: Evaluating Impact and Generalizability of Deep Learning Approaches 2023 Cancer Research Communications HNSC
Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer 2023 Clinical Cancer Research EGC, STAD, ESCA, GEJ ERBB2, KRAS, MYC, CDKN2A, CDKN2B, PIK3CA, PIK3CD, MET, EGFR, TP53, FGFR3, TACC3, CCND1, MT1H, MT1E, MT2A, MSMB
Novel Genomic Risk Stratification Model for Primary Gastrointestinal Stromal Tumors (GIST) in the Adjuvant Therapy Era 2023 Clinical Cancer Research GIST KIT, PDGFRA, SDHB, SDHA, TP53, CDKN2A, RB1, MAX, MGA, MYC
Genomic analysis and clinical correlations of non-small cell lung cancer brain metastasis 2023 Nature Communications LUAD, LUSC, NSCLC CDKN2A, CDKN2B, EGFR, MYC, TP53, KRAS, STK11, SMARCA4, RB1, ARID1A, FOXA1, NKX2-1, NF1, HLA-B, NKX3-1
Assessing the Genomic Landscape of Cervical Cancers: Clinical Opportunities and Therapeutic Targets 2023 Clinical Cancer Research CESC PIK3CA, ERBB2, KMT2C, KMT2D, KRAS, TP53, PTEN, STK11, ARID1A, FBXW7, TERT, MYC, HRAS, NRAS, BRCA1, BRCA2, SMAD4, CDKN2A, ERBB3, RNF43
Molecular characterization of endometrial carcinomas in Black and White patients reveals disparate drivers with therapeutic implications 2023 Cancer Discovery UCEC, UCS, USC TP53, CCNE1, ERBB2, PTEN, PIK3CA, PIK3R1, KRAS, ARID1A, CTNNB1, PPP2R1A, AKT2, POLE, POLD1, FBXW7, KMT2B, NF1, BRCA1, MED12
Clinical and Genomic Landscape of FGFR3-Altered Urothelial Carcinoma and Treatment Outcomes with Erdafitinib: A Real-World Experience 2023 Clinical Cancer Research BLCA, UTUC FGFR3, FGFR2, TACC3, TP53, AKT1, PIK3CA, TSC1, ERBB2, CDKN2A, CDKN1A, CDKN2B, KDM6A, RB1
Sequential genomic analysis using a multisample/multiplatform approach to better define rhabdomyosarcoma progression and relapse 2023 npj Precision Oncology RMS, ARMS, ERMS PAX3, PAX7, FOXO1, MYCN, CDKN2A, CDKN2B, CDK4, TP53, BCOR, PIK3CA, HRAS, NRAS, KRAS, MDM2, SMARCA2, AKT1, GLI1, IGF2, MED12, NCOR2, BAP1, NF1, FGFR1, RB1, MYOD1, FBXW7, DMD
Targeted Molecular Profiling of Circulating Cell-Free DNA in Patients With Advanced Hepatocellular Carcinoma 2023 JCO Precision Oncology HCC TERT, TP53, CTNNB1, ARID1A, TSC2, TSC1, PIK3CA, BRCA1, BRCA2, APC, CDKN2A, RB1, NF1, KRAS
Multimodal data integration using machine learning improves risk stratification of high-grade serous ovarian cancer 2022 Nature Cancer HGSOC BRCA1, BRCA2, CDK12, CCNE1
Molecular map of chronic lymphocytic leukemia and its impact on outcome 2022 Nature Genetics CLLSLL, MBL SF3B1, NOTCH1, ATM, TP53, BRAF, MYD88, NFKB1, RRM1, MAP2K2, DIS3, DICER1, INO80, RFX7, ARID1A, KMT2C, KMT2D, BCL2, TRAF3, ZFP36L1, FUBP1, MSL3, USP8, ZC3H18, NFKBIE, ASXL1, MYC
Multimodal integration of radiology, pathology and genomics for prediction of response to PD-(L)1 blockade in patients with non-small cell lung cancer 2022 Nature Cancer NSCLC, LUAD, LUSC EGFR, STK11, ERBB2, ARID1A, ALK, ROS1, RET, MET, BRAF
Comprehensive Molecular Characterization of Gallbladder Carcinoma and Potential Targets for Intervention 2022 Clinical Cancer Research GBC TP53, CDKN2A, CDKN2B, ERBB2, ERBB3, KRAS, SMAD4, ARID1A, ARID2, PIK3CA, ELF3, STK11, CTNNB1, KMT2C, TERT, RB1, MDM2, CCNE1, MYC, CDK4, CDK12, AKT2, AXIN1, RET, SMARCA4, FGFR3, NTRK1, BRCA1, BRCA2, ATM, TSC1, TSC2, PALB2, BRIP1, MET, RAD51D, AKT1, BRAF, EGFR, ERCC2, MAP2K1, NRAS, ROS1, NOTCH1, IDH1, BAP1
Collaborative study from the Bladder Cancer Advocacy Network for the genomic analysis of metastatic urothelial cancer 2022 Nature Communications BLCA TP53, RB1, KMT2D, ARID1A, KDM6A, KMT2C, EP300, KMT2A, CREBBP, SMARCA4, BRCA2, PRKDC, ATM, ERCC2, FANCA, FANCC, FGFR3, PIK3CA, TACC3, CCND1, MDM2, ERBB2, CCNE1, EGFR, POLE, MUTYH
Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer 2022 Nature Medicine NSCLC, LUAD, LUSC RICTOR, PIK3CA, EGFR, KRAS, TP53
Molecular Classification of Appendiceal Adenocarcinoma 2022 Journal of Clinical Oncology APAD KRAS, NRAS, GNAS, TP53
Ovarian cancer mutational processes drive site-specific immune evasion 2022 Nature HGSOC BRCA1, BRCA2, TP53, CCNE1, CDK12, MYC, CD274, PDCD1, HLA-A, HLA-B, B2M
Genomic heterogeneity as a barrier to precision oncology in urothelial cancer 2022 Cell Reports BLCA, UTUC FGFR3, ARID1A, TP53, RB1, ERBB2, PIK3CA, TSC1, KDM6A, CREBBP, CDKN1A, TERT
Whole-genome characterization of myoepithelial carcinomas of the soft tissue 2022 Cold Spring Harbor Molecular Case Studies MYEC SMARCB1, EWSR1, NF1, ELK4, ASCC2, GGNBP2, KLF15, CREB1, POLE, SMARCA2
A Clinically Applicable Integrative Molecular Classification of Meningiomas 2021 Nature MNG NF2, TRAF7, AKT1, KLF4, SMO, POLR2A, KDM6A, CHD2, PTEN, CREBBP, FBXW7, RB1, SMARCB1, DMD, FOXM1, MYC, S100B, SCGN, ACADL, MCM2
Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors 2021 Nature Communications NBL NTRK1, NTRK2, MYCN, ALK, BRCA1, BRCA2, PHOX2A, PHOX2B, TH, DBH, CHGA, CHGB, PNMT, PRPH, ISL1, SOX6, SOX10, FOXD3, S100B, ERBB3, RTTN, BCL11A, CLDN11, ASXL3, POU6F2, TP63, PROM1, LGR5, PDGFRA, PDGFRB, PRRX1, YAP1, CHRNA7, DOCK7, MKI67, USH2A
Molecular therapies and precision medicine for hepatocellular carcinoma 2018 Nature Reviews Clinical Oncology HCC TERT, TP53, CTNNB1, AXIN1, ARID1A, ARID1B, ARID2, ATM, RB1, CDKN2A, APC, KMT2A, KMT2B, KMT2C, BAP1, RPS6KA3, PIK3CA, KRAS, NRAS, PDGFRA, EGFR, PTEN, NFE2L2, KEAP1, ALB, APOB, IL6ST, JAK1, ACVR2A, IGF2R, MYC, CCND1, VEGFA, FGF19, FGFR4, MET, HGF, AXL, EPCAM, IGF2, PTK2, CD274, PDCD1, CTLA4, RAF1, BRAF, KIT
Genetic predictors of response to systemic therapy in esophagogastric cancer 2018 Cancer Discovery EGC, ESCA, STAD, GEJ, DSTAD ERBB2, TP53, ARID1A, CDKN2A, KRAS, EGFR, ERBB3, PIK3CA, FGFR2, MET, CDH1, B2M, BRCA1, BRCA2, KMT2C, GRIN2A, PTPRD, CTNNB1, CDK4, FGFR1
Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma 2018 Science CCRCC PBRM1, SMARCA4, BRD7, ARID2, VHL, B2M
Clinical sequencing defines the genomic landscape of metastatic colorectal cancer 2018 Cancer Cell COADREAD, COAD, READ APC, TP53, KRAS, PIK3CA, SMAD4, CTNNB1, RNF43, BRAF, NRAS, PTEN, AKT1, SMAD2, ERBB2, EGFR, POLE, MSH6, BRCA1, BRCA2, NTRK1, NTRK3, RET, MLH1, MSH2, PMS2, FBXW7, PTPRS, PIK3CG, FLT4, MAP2K4, IKZF1, JUN, TBX3, FOXP1, INHBA, CDKN1B, AGAP3, CUL1, LMNA, TPM3, ETV6, NCOA4, DNMT3B, SRC
Molecular Determinants of Response to Anti–Programmed Cell Death (PD)-1 and Anti–Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non–Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing 2018 Journal of Clinical Oncology NSCLC, LUAD, LUSC EGFR, STK11, KRAS, TP53, B2M, JAK1, JAK2, MDM2, MDM4, ALK, BRAF, ROS1, RET, MET, ERBB2, HLA-A, POLE, JAK3, CD274, PTEN, ATR
HER kinase inhibition in patients with HER2- and HER3-mutant cancers 2018 Nature BRCA, NSCLC, LUAD, CESC, CHOL, BLCA, COAD, SACA ERBB2, ERBB3, TP53, EGFR, PIK3CA, GRB7, BRAF, KRAS, ALK, ROS1
Mutational signatures and chromosome alteration profiles of squamous cell carcinomas of the vulva 2018 Experimental & Molecular Medicine VSC TP53, CDKN2A, HRAS, PIK3CA, BRCA2, FBXW7, FAT1, KRAS, PTEN, PPP2R1A
Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines 2018 Cell Systems PAAD, SKCM, LUAD, LUSC, BLCA, BRCA, HNSC, COAD, READ, UCEC, ESCA, CCRCC, AML, THYM, KICH, UVM, GBM TP53, PTEN, VHL, SETD2, PBRM1, BAP1, MTOR, ELOC, PIK3CA, ATM, ERBB4, SLITRK6, KDM5C, TERT, CIC, CRLF2, FOXP1, SF3B1
The long tail of oncogenic drivers in prostate cancer 2018 Nature Genetics PRAD AR, SPOP, FOXA1, TP53, PTEN, CUL3, SPEN, SF3B1, U2AF1, PIK3R2, PIK3R1, CTNNB1, APC, KRAS, BRAF, IDH1, ZMYM3, MRE11, PALB2, CDK12, BRCA2, RB1, KMT2C, KMT2D, ARID1A, ARID2, ARID4A, SMARCA1, USP28, USP7, ERG, TMPRSS2
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers 2018 Cell Reports PANCAN, PRAD, THCA, BLCA, CESC, LUSC, LUAD, CHOL, LAML, BRCA, GBM, LIHC, HNSC, UCEC, COAD, ESCA, SARC, LGG, KICH, KIRC, KIRP, MESO, PCPG, TGCT, THYM, UVM, DLBCL, FLC, PAAD, READ, OV, STAD, SKCM, ACC, UCS TMPRSS2, ERG, FGFR3, TACC3, EML4, ALK, CCDC6, RET, FGFR2, BICC1, EGFR, ERBB2, PPP1R1B, IKZF3, CBFB, MYH11, DNAJB1, PRKACA, NTRK1, NTRK3, BRAF, WNK1, WNK2, ERC1, FGR, WASF2, TRABD, DDR2, MERTK, TMEM87B, ESR1, TP53, BCR, ABL1, PML, RARA, NUP98, NSD1, EWSR1, FLI1, IGH
Genomic and Functional Approaches to Understanding Cancer Aneuploidy 2018 Cancer Cell LUSC, GBM, LGG, HNSC, CESC, ESCC, LUAD, BRCA, HCC, COAD, READ, STAD, PAAD, UCEC, UCS, UVM, TGCT, AML, THYM, BLCA TP53, POLE, IDH1, SOX2, PIK3CA, TERC, TERT, STAC, ROBO1, UBA7, LMCD1, ISG15
Imaging and clinical data archive for head and neck squamous cell carcinoma patients treated with radiotherapy 2018 Scientific Data HNSC
A radiogenomic dataset of non-small cell lung cancer 2018 Scientific Data NSCLC, LUAD, LUSC EGFR, KRAS, ALK, EML4
The Molecular Landscape of Recurrent and Metastatic Head and Neck Cancers: Insights From a Precision Oncology Sequencing Platform 2017 JAMA Oncology HNSC, ACYC, OPHSC, HNSCUP, CSCC, BCC, NPC, SDCA, ACCC, MASC, MUCC, SACA, HNNE, ONBL, AMBL, CCOC, ES, CESC TP53, TERT, NOTCH1, PIK3CA, CDKN2A, PTEN, HRAS, RB1, MAPK1, SMARCB1, FGFR3, PIK3R1, MDM2, PDGFRA, KDR, KIT, ERBB2, AR, NF1, ROS1, PTCH1, MLH1, MSH2, MSH6, POLD1, ETV6, NTRK3, EWSR1, FLI1, ATF1, FANCA
Altering the Natural History of Oligometastatic Prostate Cancer With Local Therapies: Reality Versus Illusion 2017 Journal of Oncology Practice PRAD, NSCLC
Integrated genomic characterization of oesophageal carcinoma 2017 Nature ESCA, ESCC, STAD, GEJ, HNSC TP53, NFE2L2, KMT2D, ZNF750, NOTCH1, TGFBR2, CDKN2A, ARID1A, SMAD4, ERBB2, CCND1, SOX2, TP63, VEGFA, GATA4, GATA6, CCNE1, TERT, FGFR1, MDM2, NKX2-1, RB1, VGLL4, ATG7, CDK6, EGFR, PIK3CA, PTEN, PIK3R1, KRAS, IGF1R, JUP, PTCH1, CDH1, CTNNB1, KEAP1, CUL3, YAP1, SMARCA4, PBRM1, KMT2C, KDM6A, BST2, RUNX1, APC, FHIT, WWOX, MYC, MGMT, CHFR, ALDH2, ADH1B
Comprehensive molecular characterization of pheochromocytoma and paraganglioma 2017 Cancer Cell PHC, PGNG HRAS, RET, EPAS1, NF1, CSDE1, MAML3, BRAF, NGFR, VHL, SDHB, SDHD, MAX, EGLN1, TMEM127, IDH1, FGFR1, ATRX, TP53, SETD2, ARNT, UBTF, TCF4, CHGA, PNMT, WNT4, WNT11, WNT5A, NKD1, GLI2, DVL3, GSK3B, CTNNB1, FZD8, PRKAR1A, PRKACA, CYP11B1, CYP21A2, STAR
Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis 2017 Cancer Cell SCLC SLFN11, EZH2, TWIST1, TP53, RB1, RBL2, SOX2, MYC
Prospective comprehensive molecular characterization of lung adenocarcinomas for efficient patient matching to approved and emerging therapies 2017 Cancer Discovery LUAD EGFR, KRAS, ALK, ROS1, RET, MET, BRAF, ERBB2, ERBB3, ERBB4, NF1, NRAS, HRAS, MAP2K1, ARAF, RAF1, PIK3CA, PTEN, TSC1, TSC2, AKT1, MTOR, BRCA1, BRCA2, KIT, CD74, NRG1, FGFR3, TACC3, SND1, TP53, STK11, KEAP1, NFE2L2, KMT2D, KMT2C, SETD2, CREBBP, PDGFRA, MRE11, CDKN2A, ERRFI1, KDM5C, RIT1
Integrated genomic analyses reveal frequent aberrations in acral melanoma 2017 Genome Research ACRM, SKCM TERT, PAK1, BRAF, NRAS, NF1, KIT, CCND1, CDK4, CDKN2A, GAB2, MDM2, TP53, PTEN, EGFR, KRAS, ERBB3, PREX2, CLPTM1L, ADCY2, PDCD1LG2, NIPBL, FER, PAK2, MAP3K8, DEK, HECTD4, UBE2QL1, TRIO, RAI14, PDZD2, MITF
Phylogenetic ctDNA analysis depicts early stage lung cancer evolution 2017 Nature NSCLC, LUAD, LUSC KRAS, EGFR, TP53, ERBB2, ARID1A
Multicenter phase II study of temozolomide and myeloablative chemotherapy with autologous stem cell transplant for newly diagnosed anaplastic oligodendroglioma 2017 Neuro-Oncology ODG3, ODG IDH1, IDH2, TERT, CIC, FUBP1, NOTCH1, NOTCH2, EGFR, NF1, MDM2, PTEN, CDKN2A, CDKN2B, CDK4, TSC1, PIK3CA, PIK3R1, KRAS, SMARCA4, FBXW7, APC, ARID1A, ATRX, BCOR, CCND1, ETV1, FAT1, GLI1, KDM6A, MSH2, PBRM1, RASA1, SETD2, TP53
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients 2017 Nature Medicine PRAD, BRCA, LUAD, SCLC, COAD, READ, PAAD, HGSOC, STAD, ESCA, EGC, UCEC, GB, MEL, BLCA, THYC, CHRCC, GIST, ES, FLC TP53, KRAS, PIK3CA, BRAF, EGFR, TERT, AR, ESR1, VHL, APC, IDH1, ALK, RET, ROS1, MET, TMPRSS2, ERG, EML4, EWSR1, FLI1, DNAJB1, PRKACA, POLE, CDK5RAP2
Somatic mutation profiles of clear cell endometrial tumors revealed by whole exome and targeted gene sequencing 2017 Cancer UCCC, UCEC, USC, UEC TP53, PIK3CA, PIK3R1, ARID1A, PPP2R1A, SPOP, TAF1, FBXW7, KMT2C, PTEN, KRAS, POLE, MSH6
Next-generation Sequencing of Nonmuscle Invasive Bladder Cancer Reveals Potential Biomarkers and Rational Therapeutic Targets 2017 European Urology BLCA TERT, FGFR3, KDM6A, PIK3CA, STAG2, ARID1A, TP53, ERBB2, ERCC2, ATM, BRCA1, BRCA2, ERCC4, PALB2, CHEK2, FANCC, MSH6, POLE, MDM2, RB1, CCND1, CDKN1A, CDKN2A, TACC3, TNIP2
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma 2017 Cancer Discovery CHOL, IHCH, EHCH, PHCH ERBB2, TP53, ARID1A, BRCA1, BRCA2, CTNNB1, WNT5B, AKT1, BAP1, IDH1, IDH2, FGFR2, FGFR3, TACC3, BICC1, PRKACB, RASA1, STK11, MAP2K4, SF3B1, KRAS, TERT, FBXW7, SMAD4, MYC, MDM2, EGFR, CCND1, CDKN2A, UTY, KDM5D, TTC28, POLE, PDCD1, PDCD1LG2, BTLA, TET1, EZH2
The whole-genome landscape of medulloblastoma subtypes 2017 Nature MBL KBTBD4, PRDM6, SNCAIP, CTNNB1, PTCH1, DDX3X, KMT2D, SMARCA4, KMT2C, KDM6A, TP53, SUFU, APC, CSNK2B, EPHA7, ARID1A, ARID2, CREBBP, EP300, KAT6B, BRPF1, KANSL1, IDH1, SMO, TERT, MYC, MYCN, GFI1, GFI1B, OTX2, ZMYM3, CTDNEP1, ZIC1, GSE1, TCF4, FBXW7, BCOR, CHD7, CDK6, MED12, STAG2, GLI2, PTEN, PVT1, POLE, MLH1, BRCA2, FLG
Integrative Clinical Genomics of Metastatic Cancer 2017 Nature MIXED, PRAD, BRCA, SARCNOS, CUP, ULMS TP53, CDKN2A, PTEN, RB1, PIK3CA, AR, KRAS, GNAS, NF1, BRCA1, BRCA2, MUTYH, CHEK2, APC, MITF, HOXB13, MLH1, NBN, ALK, BRAF, GREB1, NR4A3, POC5, PRKD1, CITED1, SPAG17, PARS2
Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making 2017 JCO Precision Oncology PRAD AR, TP53, PTEN, RB1, BRCA2, BRCA1, ATM, CHEK2, FANCA, CDK12, PALB2, RAD50, MSH2, MLH1, MSH6, PMS2, BRIP1, NBN, FH, APC, CTNNB1, RNF43, SPOP, FOXA1, PIK3CA, PIK3R1, AKT1, AKT3, BRAF, HRAS, KRAS, MAP2K1, EP300, KDM5A, KMT2D, ARID5B
Advancing The Cancer Genome Atlas glioma MRI collections with expert segmentation labels and radiomic features 2017 Scientific Data GB, DIFG
Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma 2017 Cell DLBCLNOS, BL MYC, BCL2, BCL6, CARD11, IRF4, SPEN, CDKN2A, TNFAIP3, EZH2, SGK1, GNA13, SOCS1, STAT6, TNFRSF14, ETV6, MYD88, PIM1, TBL1XR1, TP53, KLHL6, KMT2D, RHOA, SF3B1, MTOR, MGA, PTEN, NCOR1, EBF1, IKBKB, ZBTB7A, XPO1, TGFBR2, PTPN6, CD79B, ZFAT, NF1, KLHL14, BTG1, PAX5, CREBBP, NFKBIA, ARID5B, PIK3R1, PIM2, BTK, CHD8, POU2F2, YY1, H1-4, NOTCH2, PIK3CD, JAK2, RB1, CD70
Comprehensive molecular characterization of muscle invasive bladder cancer 2017 Cell BLCA FGFR3, TACC3, TP53, RB1, ERCC2, PPARG, CDKN2A, CDKN1A, ATM, ERBB2, PIK3CA, KRAS, MDM2, KMT2C, KMT2A, KMT2D, KDM6A, CREBBP, EP300, KANSL1, ARID1A, ASXL1, ASXL2, STAG2, FAT1, CASP8, CDH1, SPTAN1, E2F3, SOX4, POLE, RAD51B, APOBEC3A, APOBEC3B, GATA3, FOXA1, EGFR, CD274, PDCD1, CTLA4, TP63, KLF4, BRD4, EZH2, MYCL, NECTIN4, CCND1, CCNE1, AHR, TERT, YWHAZ, ZNF703, BCL2L1, MALAT1, NEAT1, UCA1, LXN, PARP6, NAPRT, UPK2, UPK1A, KRT20, KRT5, KRT6A, KRT14, CD44
Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab 2017 Cell SKCM B2M, CDKN2A, JAK1, JAK2, SERPINB3, SERPINB4, NF1, PTEN, PDCD1, CD274, CTLA4, CD80, CD86, CD28, CD247, CD3D, CD3E, CD3G, PTPN6, ICOS, LAG3, TNFRSF9, TNFRSF4, TIGIT, HAVCR2, VSIR, GZMA, PRF1, FGFR3, IL17RE, IL17RC, FOXP3
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas 2017 Cell SARCNOS, DDLS, LMS, ULMS, USARC, MFS, MPNST, SS TP53, ATRX, RB1, MDM2, CDK4, CDKN2A, HMGA2, FRS2, NAV3, JUN, DDIT3, PTPRQ, YAP1, CEBPA, NF1, NF2, PRKDC, TERT, TRIO, FGFR3, SS18, SSX1, SSX2, PTEN, AKT3, MTOR, IGF1R, RICTOR, MYOCD, VGLL3, CCNE1, CCNE2, MCM2, FANCI, CD274, ESR1, MSH6, MSH2, MYLK, MYH11
Novel MYBL1 gene rearrangements with recurrent MYBL1-NFIB fusions in salivary adenoid cystic carcinomas lacking t(6;9) translocations 2016 Clinical Cancer Research ACYC MYBL1, MYB, NFIB, YTHDF3, XRCC4, NKAIN2, PTPRD, AIG1, RAD51B, NOTCH1, SPEN, MUC16, MUC12, TFAP4, MAP10
Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4 2016 Oncotarget UM PLCB4, PLCB3, GNAQ, GNA11, BAP1, SF3B1, EIF1AX, LLGL1, MUC3A, TCHH, TTN, GSPT1, HSD17B3, FAM135B, PDSS2
Divergent clonal selection dominates medulloblastoma at recurrence 2016 Nature MBL TP53, PTCH1, DYNC1H1, SMO, MYC, TERT, CDKN2A, CDKN2B, CREBBP, ARID1B, TCF4
Ampullary cancers harbor ELF3 tumor suppressor gene mutations and exhibit frequent WNT dysregulation 2016 Cell Reports AMPCA, DA, EHCH ELF3, TP53, KRAS, SMAD4, CDKN2A, APC, SOX9, TGFBR2, PBRM1, RECQL4, KDM6A, ARID1A, ARID2, PMS2, KDM4C, UHRF2, CTNNB1, MET, SLC45A3, ELK4, IDH1, BAP1
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma 2016 Cell DIFG, GBM, ASTR, ODG, PAST IDH1, IDH2, TERT, ATRX, TP53, EGFR, PTEN, CIC, FUBP1, SETD2, ARID2, DNMT3A, KRAS, NRAS, CDK4, CDKN2A, CDKN2B, BRAF, NF1, NTRK1, NTRK2, FGFR1, FGFR2, STAG2, NIPBL, TRIM28, CACNG6, DAXX, H3-3A, SOX2, OLIG2
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma 2016 Nature Genetics ACYC MYB, NFIB, TGFBR3, RAD51B, TP63, NOTCH1, SPEN, ARID1A, BRD4, JAG1, JAG2, EN1, RBPJ, KIT, MYC, BCL2, CDK6
Divergent clonal evolution of castration resistant neuroendocrine prostate cancer 2016 Nature Medicine PRAD AR, RB1, TP53, BRCA2, MYCN, CYLD, DEK, SBDS, FOXA1, NCOR1, NCOR2, ZBTB16, EZH2, SPDEF, AURKA, NCAM1, PEG10, DKK1, NKD1, TMPRSS2, ERG
Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma 2016 Cancer Prevention Research ACYC NFIB, MYB, MYBL1, MAP3K5, RIMS1, MYO6, RPS6KA2, NOTCH1, NOTCH2, KMT2D, KMT2C, EP300, SMARCA2, SMARCC1, KDM6A, RHOA, ARHGEF3, ARHGEF5, ARHGEF18, CDH2, CDH13, ACTB, PLXNB1, PLXNA1, PRKD1, SLIT1, SRGAP2, SRGAP3, SEMA3G, SEMA5A, NTNG1, ADAM2, ADAMTS5, ADAMTS13, DUX4
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers 2016 Journal of Clinical Investigation THPD, THAP, THPA BRAF, NRAS, HRAS, KRAS, TERT, TP53, EIF1AX, PIK3CA, PTEN, NF1, NF2, ATM, PIK3C2G, PIK3CG, PIK3C3, PIK3R1, PIK3R2, AKT3, TSC1, TSC2, MTOR, ARID1A, ARID1B, ARID2, ARID5B, SMARCB1, PBRM1, ATRX, KMT2A, KMT2C, KMT2D, SETD2, MSH2, MSH6, MLH1, CTNNB1, AXIN1, APC, CDKN1B, CDKN2C, CDKN2A, ERBB2, PTCH1, DAXX, RB1, MEN1, TSHR, STK11, RET, CCDC6, NCOA4, PAX8, PPARG, ALK, STRN, EML4, CCDC149, NUTM1, BRD4, EPHA3, EGFR, FLT1, FLT4, KDR, NOTCH1, NOTCH2, NOTCH3, NOTCH4, CREBBP, EP300, BCOR, BCL6, DIS3, FAT1, POLE, RBM10, RAD54L, RECQL4, SF3B1
Frequent somatic CDH1 loss-of-function mutations in plasmacytoid-variant bladder cancer 2016 Nature Genetics SRCBC, BLCA CDH1, TP53, RB1, ARID1A, ERBB2, PIK3CA, CDKN1A, PIK3C2G, PTEN, NOTCH2, FAT4, TSC1
Substantial inter-individual and limited intra-individual genomic diversity among tumors from men with metastatic prostate cancer 2016 Nature Medicine PRAD AR, ERG, TP53, RB1, SPOP, CHD1, ZBTB16, MYC, FOXA2, MSH2, MSH6, TMPRSS2, NR3C1, PGR, ESR1, E2F1, FANCA, FANCI, FANCD2, BRCA1, BRCA2, PALB2, ATM, FANCB, FANCC, FANCE, FANCF, FANCG, BRIP1, FANCL, FANCM, SLX4, PTEN, CSMD1, NCOR2
Genome-wide profiles of extra-cranial malignant rhabdoid tumors reveal heterogeneity and dysregulated developmental pathways 2016 Cancer Cell MRT, MRTL SMARCB1, SMARCA4, DSCAM, SPECC1L, KCNJ3, NF2, LIF, SMARCE1, HOTAIR, BMP4, WNT5A, STAT3, FLT3LG, ZIC3, SOX3, DLK1, MEOX2, PCDH18, TCF21, MEIS1
Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma 2016 Cell SKCM, MEL BRCA2, AXL, ROR2, WNT5A, LOXL2, TWIST2, TAGLN, FAP, IL10, VEGFA, VEGFC, CCL2, CCL7, CCL8, CCL13, CDH1, PTEN, PDCD1, CD274, PDCD1LG2, CTLA4, LAG3, IFNG, GZMA, PRF1, BRAF
Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma 2016 Cell Reports COADREAD BCL9L, RBM10, RBM12, CTCF, KLF5, TGIF1, TCF7, PRKCQ, MAP2K1, MAP2K7, PTEN, RB1, RNF43, KRAS, NRAS, POLE, B2M, CALR, CANX, HSPA5, PDIA3, TAP1, TAP2, TAPBP
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas 2016 Nature Genetics LUAD, LUSC, NSCLC TP53, RB1, ARID1A, CDKN2A, PIK3CA, NF1, STK11, RBM10, KEAP1, RAF1, RIT1, MET, EGFR, KRAS, ERBB2, ALK, ROS1, BRAF, NTRK1, NTRK2, NFE2L2, KDM6A, RASA1, NOTCH1, HRAS, AKT1, CDK4, DNMT3A, PPP3CA, DOT1L, KMT2C, SETD2, CMTR2, SF3B1, SNRPD3, SMARCA4, CUL3, KLF5, FBXW7, EP300, CREBBP, NKX2-1, MYC, TERT, MCL1, MDM2, SOX2, CCND1, WHSC1L1, FGFR1, KAT6A, ZNF217, MYCL, IGF1R, KDM5A, PTP4A1, PHF3, CCND3, MIR21, TUBD1, YES1, MIR205, MAPK1, ARID2, ZMYND11, ROBO1, USP22, B2M, TRAF3, MAP2K1, CAPZA2, KIF5B, TRIM24, TP63, PDGFRA, KIT, KDR, SOS1, VAV1, ARHGAP35, U2AF1, PASK, MLH1, MB21D2, HLA-A, HLA-B, PDCD1, CD274
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes 2016 Nature Communications BRCA PIK3CA, TP53, MUC16, AHNAK2, SYNE1, KMT2C, GATA3, BRCA1, BRCA2, CHEK2, TBX3, CBFB, RUNX1, SF3B1, AGTR2, ARID1A, PBRM1, CDKN2A, KDM6A, AFDN, FOXO3, CTNNA1, FOXP1, MEN1, KRAS, HRAS, BRAF, SMAD4, ERBB2, PTEN, AKT1, PIK3R1, RB1, CDH1, MAP3K1, NCOR1, CTCF, MAP2K4, BAP1, CDKN1B, GPS2, ZFP36L1, TBL1XR1, USP9X, NF1, CCND1, PAK1, ZNF703, MYC, JAK1, NT5E
Genomic Classification and Prognosis in Acute Myeloid Leukemia 2016 New England Journal of Medicine AML NPM1, DNMT3A, FLT3, NRAS, TP53, IDH1, IDH2, TET2, ASXL1, SRSF2, SF3B1, U2AF1, ZRSR2, STAG2, BCOR, KMT2A, EZH2, PHF6, RUNX1, CEBPA, BRAF, MYC, PTPN11, WT1, KIT, GATA2, RAD21, MECOM, PML, RARA, CBFB, MYH11, RUNX1T1, DEK, NUP214, MLLT3
Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors 2016 Journal of Clinical Oncology GCT, NSGCT, SEM, MGCT, TT TP53, MDM2, MYCN, KRAS, NRAS, BRAF, KIT, RAC1, CBL, GNAQ, KDR, MET, PIK3CA, PTEN, AKT1, MTOR, TSC1, TSC2, APC, FAT1, AXIN1, EP300, SETD2, PTPRD, BRCA2, MAX, MCL1, CCND3
Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize 2016 Nature Communications HNSC, NSCLC, ESCA, BRCA, STAD, COAD, GB EGFR, ERBB2
Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets 2016 Nature Communications URCC, RCC, NCCRCC, CCRCC, PRCC, CHRCC, TRCC NF2, SETD2, BAP1, KMT2C, MTOR, TSC1, TSC2, PTEN, FH, ALK, TPM3, KMT2D, ATRX, DNMT3A, SMARCB1, KLF6, NOTCH2, TP53, PBRM1, CHEK2, BRCA2, KMT2A, MET, BRAF, VHL, YAP1, WWTR1
Clonal Evolution of Chemotherapy-resistant Urothelial Carcinoma 2016 Nature Genetics BLCA TP53, PIK3CA, KMT2D, ATM, TSC1, CDKN2A, CDKN2B, MTAP, RB1, FANCC, ERCC2, L1CAM, APOBEC3A, APOBEC3B, E2F3, SETDB1, MLLT11, TSPAN8, RYR2, ANKRD62, NCOA3, LSS, POLD2, FOXP1, FGFR4, TRRAP, EGFR
Deregulation of DUX4 and ERG in acute lymphoblastic leukemia 2016 Nature Genetics BLL DUX4, ERG, IKZF1, PAX5, MYC, MYCBP2, MGA, ZEB2, KMT2D, SETD2, ARID2, NCOR1, NRAS, NSD1, RNGTT
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma 2016 Nature ODG IDH1, IDH2, CIC, OLIG1, OLIG2, OMG, APOE, ALDOC, SOX9, SOX4, SOX11, SOX2, NFIB, ASCL1, CHD7, CD24, BOC, TCF4, CCND2, CCND1, CCND3, ETV1, ETV5, GFAP, MKI67
A current perspective on stereotactic body radiation therapy for pancreatic cancer 2016 OncoTargets and Therapy PAAD SMAD4, TGFB1, TGFBR2
TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes 2016 New England Journal of Medicine AML, MDS TP53, DNMT3A, IDH1, IDH2, ASXL1, SRSF2, U2AF1, SF3B1, TET2, PPM1D, RUNX1
Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations 2016 Genome Medicine AML, JMML, AMKL, CML, BLL, BLLNOS, TLL, ALCL, HL, PTLD, NBL, OS, ES, ARMS, ERMS, IFS, ASPS, DSRCT, MBL, EPM, EPMT, HGGNOS, DIFG, PXA, ATRT, MRT, MRTL, LIHB, HCC, WT, RCC, ACC, PB, PPB, IMT, PINT TP53, KRAS, NRAS, KIT, TET2, FLT3, JAK1, JAK3, IDH1, PTPN11, SETBP1, CEBPA, STAT5B, PIK3CA, TSC1, SMARCA4, SMARCB1, SMARCC2, PTCH1, SUFU, ZIC3, FGFR1, FGFR4, H3-3A, CDK2, CDK4, MDM2, MCL1, CCNE1, CUL4A, RAD51C, PDGFRA, PDGFRB, KDR, MYC, MYCN, CCND1, ATRX, KDM6A, DICER1, VHL, APC, ATM, BRCA1, PMS2, C1QA, XIAP, RUNX1, GATA2, KMT2A, KMT2C, KMT2D, AFF1, NUP98, NSD1, NUP214, ABL1, BCR, FOXP1, NT5C2, PAX7, FOXO1, EWSR1, FLI1, WT1, ASPSCR1, TFE3, CBFB, MYH11, CBFA2T3, GLIS2, EML4, NTRK3, VCAN, IL23R, TMEM106B, BRAF, RELA, RB1, TNNT2, RYR1, ITK, SDHC, ALK, UGT1A1, ASCL1
Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis 2016 PLOS Medicine BRCA, IDC, ILC TP53, PIK3CA, GATA3, ESR1, MAP3K1, CDH1, AKT1, MAP2K4, RB1, PTEN, CBFB, CDKN2A, FSIP2, FRAS1, OSBPL3, EDC4, PALB2, IGFN1, AGRN, TSC1, TSC2, ERBB4, NOTCH3, ALK, EZH2, BRAF, ERBB2, CCND1, MYC, APOBEC3B
Genomic Predictors of Survival in Patients with High-Grade Urothelial Carcinoma of the Bladder 2015 European Urology BLCA PIK3CA, TP53, CDKN2A, KDM6A, ARID1A, STAG2, KMT2D, SMARCA4, CREBBP, EP300, PTEN, AKT1, TSC1
Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes 2015 Nature Genetics PRCC, CHRCC, TRCC, ROCY MET, NF2, SLC5A3, PNKD, CPQ, LRP2, CHD3, NHERF1, SETD2, CRTC1, TP53, PTEN, FAAH2, PDHB, PDXDC1, ZNF765, PRKAG2, PRKAG1, TSC1, TSC2, MTOR, ARID1A, ERCC2, C2CD4C, IDH2, JAK2, ACTG1, MITF, TFE3, TFEB, TFEC, ASPSCR1, CLTC, MIDN, SBNO2, BIRC7, FH, VHL, FLCN, SDHB, SDHC, SDHD, BAP1, HIF1A, APEX1
Dynamics of genomic clones in breast cancer patient xenografts at single cell resolution 2015 Nature BRCA TP53
Mutational landscape of gastric adenocarcinoma in Chinese: Implications for prognosis and therapy 2015 Proceedings of the National Academy of Sciences (PNAS) STAD TP53, ARID1A, NRG1, ERBB4, ERBB2, BRCA2, BRCA1, CDH1, APC, RHOA, PIK3CA, SMAD4, MYC, KRAS, MSH6, TGFBR2, KMT2D, KDM5A, SETBP1, AKAP9, CDK6, CACNA1D
Novel recurrently mutated genes in African American colon cancers 2015 Proceedings of the National Academy of Sciences COAD EPHA6, FLCN, MAGEB10, CPT1C, HTR1F, ANKRD36, MGAT4C, ZNF717, ZNF862, CP, CCDC74A, EML6, ATP8B2, JAK1, CHD5, WASHC1, GPR149, CDK8, WDR87, APC, TP53, KRAS, PIK3CA, SMAD4, BRAF, FBXW7, EPHA3, EPHB6
Genomic analysis of metastatic cutaneous squamous cell carcinoma 2015 Clinical Cancer Research CSCC TP53, CDKN2A, CDKN2B, NOTCH1, NOTCH2, NOTCH4, RIPK4, SMAD4, BRAF, KRAS, HRAS, EGFR, FGFR3, KIT, ERBB4, PIK3CA, HGF, MTOR, STK11, PTEN, NF1, EZH2, CARD11, CREBBP, EP300, KMT2D, ARID1A, ARID2, ARID5B, SMARCA4, SMARCB1, NF2, TP63, MYC, CCND1, CDK4, CDK6, RB1, ATR, NFKBIA, LAMA5, FANCC, SDHB, SOX2, KNSTRN, STK19, VEGFA
Comprehensive genomic characterization of head and neck squamous cell carcinomas 2015 Nature HNSC, OCSC, OPHSC, LXSC, HPHSC TP53, PIK3CA, CDKN2A, TRAF3, E2F1, HRAS, CASP8, NOTCH1, AJUBA, FAT1, NSD1, NFE2L2, KEAP1, CUL3, CCND1, FADD, CTTN, BIRC2, YAP1, EGFR, ERBB2, FGFR1, FGFR2, FGFR3, IGF1R, DDR2, EPHA2, MET, MYC, PTEN, PIK3R1, RB1, KMT2D, HLA-A, TGFBR2, FBXW7, SOX2, TP63, ZNF750, SMAD4, NF1, CDK6, PLK1, HMGA2, B2M, CTNNB1, PTCH1, CHEK2, SCN9A
The landscape of somatic mutations in Infant MLL rearranged acute lymphoblastic leukemias 2015 Nat Genet BLLKMT2A, TLL KMT2A, FLT3, KRAS, NRAS, CREBBP, NT5C2, TP53
Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer 2015 Science NSCLC POLD1, POLE, MSH2, PRKDC, RAD17, POLR2A, KEAP1, KRAS, CD274, HERC1, PAPPA2, PXDNL, RYR1, SCN8A, SLIT3
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets 2015 Nature Genetics HCC TP53, CTNNB1, AXIN1, ALB, ARID1A, ARID2, ACVR2A, NFE2L2, RPS6KA3, KEAP1, RPL22, CDKN2A, CDKN1A, RB1, TERT, FGF3, FGF4, FGF19, CCND1, VEGFA, MET, MYC, JAK3, CCNE1, CFH, IRF2, PTPN3, PTEN, ZNRF3, USP34, MACF1, APOB, FGA, HNF1A, IL6ST, NQO1, HGF, SMARCA2, BRAF, ERBB2, JAK1, KDR, MTOR, EGFR, KIT, TEK, EPHA4, IL6R, PIK3CA, KRAS
Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets 2015 Nature Communications PAAD, PAASC, PAAC, IPMN KRAS, TP53, SMAD4, CDKN2A, CDKN2B, BRAF, PIK3CA, ARID1A, ARID1B, RBM10, MYC, RNF43, GNAS, ATM, BRCA1, BRCA2, CCND1, CDK4, RB1, AXIN1, AXIN2, APC, CTNNB1, GLI2, GLI3, SMO, PTCH1, LRP2, BCLAF1, IRF6, FLG, FANCF, FANCA, FANCD2, FANCM, ACVR1B, ACVR1C, TGFBR1, TGFBR2, TGFB1, SMAD3, SMAD6, NOTCH1, NOTCH2, NOTCH3, NOTCH4, JAG1, JAG2, MAML1, MAML2, MAML3, STK11, CHEK2, ATXN1, COL14A1, RP1L1, ITGAE, SPTA1, NIN, HDAC2, PABPC1, USP10, CDH13, MSH2, MSH6, MLH1, MLH3, PMS2, POLE, EXO1, SMARCA2, SMARCA4, SMARCC1, SMARCC2, PBRM1, TERT, PDGFA
Genome-wide analysis uncovers novel recurrent alterations in primary central nervous system lymphomas 2015 Clinical Cancer Research PCNSL, DLBCLNOS PRKCD, TOX, MYD88, CDKN2A, CDKN2B, TNFAIP3, PRDM1, TMEM30A, TBL1XR1, B2M, CD58, CD79B, CARD11, BCL6, FOXP1, GNA13, PIM1, BTG2, BRAF, BCL10, BCL7A, ETV6, TCF4, TNFRSF10A
Integrative clinical genomics of advanced prostate cancer 2015 Cell PRAD AR, TP53, PTEN, ETV1, ERG, FLI1, ETV4, ETV5, PIK3CA, PIK3CB, AKT1, BRAF, RAF1, APC, CTNNB1, RNF43, ZNRF3, RSPO2, ZBTB16, BRCA1, BRCA2, ATM, CDK12, FANCA, RAD51B, RAD51C, MLH1, MSH2, MSH6, SPOP, FOXA1, NCOR1, NCOR2, RB1, CCND1, CDKN2A, CDKN2B, CDKN1B, CDK4, MYC, CHD1, KMT2D, GNAS
Genomic Classification of Cutaneous Melanoma 2015 Cell SKCM BRAF, NRAS, HRAS, KRAS, NF1, CDKN2A, CDKN2B, TP53, PTEN, RAC1, MAP2K1, MAP2K2, PPP6C, ARID2, IDH1, RB1, DDX3X, MRPS31, RPS27, KIT, PDGFRA, KDR, CDK4, CCND1, MDM2, TERT, MITF, CD274, PDCD1, AKT1, AKT3, PIK3CA, GNAQ, GNA11, CTNNB1, EZH2, SF3B1, BAP1, BCL2, LCK, SYK, RAF1, HMGA2, MAPK1, MAPK3, IGFBP2, FOXP1
Genomic landscape of adenoid cystic carcinoma of the breast 2015 J Pathol ACBC, BRCA MYB, NFIB, TLN2, BRAF, FBXW7, SF3B1, FGFR2, SMARCA5, MTOR, RASA1, PTPN11, PRKD1, ARAF, CDH1, KMT2D, TP53, PIK3CA
Comprehensive genomic profiles of small cell lung cancer 2015 Nature SCLC TP53, RB1, TP73, NOTCH1, NOTCH2, NOTCH3, NOTCH4, CREBBP, EP300, RBL1, RBL2, PTEN, BRAF, KIT, PIK3CA, CCND1, CDKN2A, FHIT, ROBO1, MYC, MYCN, MYCL, FGFR1, IRS2, ASCL1, DLK1, CHGA, GRP, SYP, NCAM1, HES1, COL22A1, RGS7, FPR1, ASPM, ALMS1, PDE4DIP, XRN1, PTGFRN, FMN2, TTC28, CDKAL1, CRACDL
Genomic Characterization of Upper Tract Urothelial Carcinoma 2015 European Urology UTUC, BLCA FGFR3, HRAS, TP53, RB1, CDKN2B, CDKN2A, KDM6A, KMT2D, ARID1A, TSC1, CREBBP, PIK3CA, TACC3, POLE, MDM2, KRAS, CCND1, ERBB2, ERBB3, STAG2, KMT2A, KMT2C, EP300, SMARCA4, INPP4A
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway 2015 Nature Genetics DESM, MEL NFKBIE, NF1, CBL, ERBB2, MAP2K1, MAP3K1, BRAF, EGFR, PTPN11, MET, RAC1, SOS2, NRAS, PIK3CA, TP53, CDKN2A, FBXW7, ARID2, RB1, ARID1A, CDK4, MDM2, TERT, YAP1, CCND1, MYC, EZH2, IDH1, PPP6C, FSIP1, CDH2, IL36A, PAK3, CCNE1
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma 2015 Science SKCM, MEL BRAF, NRAS, CTLA4, PDCD1LG2, GZMA, PRF1
Comprehensive molecular portraits of invasive lobular breast cancer 2015 Cell BRCA, ILC, IDC, MIXED CDH1, PTEN, TBX3, FOXA1, GATA3, PIK3CA, RUNX1, TP53, MYC, CCNE1, ERBB2, EGFR, ESR1, AKT1, MET, KIT, PDGFRA, IDO1, IFNG, EP300, MAPK3, RB1, JAK2, TYK2, BRCA2
Telomerase activation by genomic rearrangements in high-risk neuroblastoma 2015 Nature NBL TERT, MYCN, ATRX, ALK, SLC6A18, SLC6A19, CLPTM1L
Mutations driving CLL and their evolution in progression and relapse 2015 Nature CLLSLL RPS15, IKZF3, MGA, BRAF, TP53, ATM, SF3B1, NRAS, KRAS, MAP2K1, BIRC3, MYD88, CHD2, DDX3X, BCOR, PTPN11, FUBP1, XPO4, EWSR1, NXF1, CHEK2, BRCC3, ELF4, DYRK1A, ASXL1, H1-5, BAZ2B, TRAF2, TRAF3, CARD11, POT1, EGR2, XPO1
The Molecular Taxonomy of Primary Prostate Cancer 2015 Cell PRAD ERG, ETV1, ETV4, FLI1, SPOP, FOXA1, IDH1, TMPRSS2, SLC45A3, NDRG1, TP53, PTEN, CHD1, MED12, CDKN1B, BRAF, HRAS, AKT1, PIK3CA, PIK3CB, CTNNB1, ATM, BRCA1, BRCA2, CDK12, FANCD2, RAD51C, KDM6A, KMT2C, KMT2D, APC, NKX3-1, ZMYM3, MYC, CCND1, FGFR1, WHSC1L1, MAP3K1, MAP3K7, RB1, SPINK1, AR, SPOPL, FOXP1, RYBP, SHQ1, MTOR, RAC1, RRAS2
The mutational landscape of cutaneous T-cell lymphoma and Sézary syndrome 2015 Nature Genetics SS, MYCF TP53, RB1, PTEN, DNMT3A, CDKN1B, TET2, CREBBP, KMT2D, KMT2C, BRD9, SMARCA4, CHD3, MAPK1, BRAF, CARD11, PRKG1, JAK3, SH2B3, STAT3, PREX2, PLCG1, TNFRSF1B
The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma 2014 Cancer Discovery SKCM BRAF, NRAS, MAP2K1, MAP2K2, MITF, NF1, PTEN, PIK3CA, PIK3R1, RAC1, HOXD8
Whole exome sequencing of pancreatic neoplasms with acinar differentiation 2014 Journal of Pathology PAAC, PB SMAD4, TP53, GNAS, RNF43, MEN1, ATM, BRCA2, PALB2, JAK1, BRAF, RB1, APC, PTEN, ARID1A, KMT2C, BAP1, CDKN2A, KRAS, CTNNB1, MSH2, MSH3, MLH1, MLH3, PMS2, BRCA1
Mutational Analysis Reveals the Origin and Therapy-driven Evolution of Recurrent Glioma 2014 Science ASTR, GBM, DIFG IDH1, TP53, ATRX, SMARCA4, BRAF, RB1, CDKN2A, CDK4, PIK3CA, PTEN, MTOR, MSH6, MGMT
Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy 2014 Cancer Cell PCM KRAS, NRAS, BRAF, TENT5C, TP53, DIS3, TRAF3, CYLD, RB1, PRDM1, IRF4, SP140, EGR1, CDKN2C, BIRC2, BIRC3, PTPRD, BLK, MSRA, PINX1, SOX7, MAX, MYC, CCND1, CDKN1B, FGFR3, MYD88, CARD11, BCL2
Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors 2014 Cancer Discovery RMS, ARMS, ERMS PAX3, PAX7, FOXO1, NCOA1, INO80D, NRAS, KRAS, HRAS, NF1, BRAF, PIK3CA, PIK3CD, PTEN, FGFR4, PDGFRA, ERBB2, ERBB4, FBXW7, BCOR, CTNNB1, TP53, BUB1B, FOXM1, CCND1, CCND2, PTPN11, ATM, ZNF350, TRPC4AP, ARID1A, IGF1R, IGF2, CDK4, MDM2, FRS2, MYCN, CDKN2A, MIR17HG, MYOD1, MET, CNR1, RPTOR, CACNA1A, NRG1, FOXP2
Comprehensive molecular characterization of urothelial bladder carcinoma 2014 Nature BLCA TP53, ARID1A, KMT2D, KDM6A, PIK3CA, EP300, CDKN1A, RB1, ERCC2, FGFR3, STAG2, ERBB3, FBXW7, RXRA, ELF3, NFE2L2, TSC1, KLF5, TXNIP, FOXQ1, CDKN2A, FOXA1, PAIP1, HRAS, ZFP36L1, CCND3, ERBB2, ATM, CTNNB1, TACC3, MDM2, PPARG, E2F3, CCND1, EGFR, NECTIN4, BCL2L1, ZNF703, CCNE1, AKT3, TSC2, CREBBP, APOBEC3B, RHOB, BTG2, GATA3
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing 2014 Nature Genetics CCRCC VHL, PBRM1, BAP1, SETD2, KDM5C, PTEN, MTOR, TP53, PIK3CA, ARID1A, SMARCA4, ELOC
Recurrent SMARCA4 mutations in small cell carcinoma of the ovary 2014 Nature Genetics SCCO, LUAD, BLCA, STAD SMARCA4, SMARCA2, ARID1A, ARID1B, PBRM1, TP53
Genomic and molecular characterization of esophageal squamous cell carcinoma 2014 Nature Genetics ESCC FAT1, FAT2, FAT3, ZNF750, KMT2D, KMT2C, KDM6A, ARID2, PBRM1, XPO1, FBXW7, IL7R, JAK1, SOX2, FGFR1, MAP3K13, MAP3K15, ERBB4, PTEN, PIK3CA, TP53, NOTCH1, CCND1, EGFR, MYC, KRAS, CDKN2A, APOBEC3B
Molecular Profiling of Liver Tumors: Classification and Clinical Translation for Decision Making 2014 Seminars in Liver Disease HCC, LIAD TERT, TP53, CTNNB1, AXIN1, ARID1A, ARID2, RPS6KA3, PIK3CA, IRF2, NFE2L2, KEAP1, CDKN2A, MET, FGF19, VEGFA, MYC, IGF2, IGF2R, IGF1R, EGF, EGFR, BRAF, RAF1, ERBB2, BCR, ABL1, ALK, EML4, EPCAM, KRT19, GPC3, HSPA1A, GLUL, MICA, DEPDC5, KIF1B, UBE4B, PGD, DLC1, STAT4, ABCB11, LRP2, TAF9, RAN, RAMP3, JPT1
Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach 2014 Nature Communications NSCLC, HNSC
A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors 2014 Nature Genetics TET, THYM, THYC GTF2I, TP53, CYLD, CDKN2A, BAP1, PBRM1, BCL2, KIT, BRD4, NUTM1, FOS
Copy number alteration burden predicts prostate cancer relapse 2014 Proceedings of the National Academy of Sciences PRAD PTEN, MYC, TP53, RB1, FOXP1, RYBP, SHQ1
Comprehensive molecular characterization of gastric adenocarcinoma 2014 Nature STAD PIK3CA, JAK2, CD274, PDCD1LG2, ARID1A, BCOR, TP53, KRAS, ERBB2, ERBB3, EGFR, MLH1, CDKN2A, RHOA, CDH1, CLDN18, ARHGAP26, ARHGAP6, RNF43, B2M, NF1, APC, CTNNB1, SMAD4, SMAD2, RASA1, FGFR2, MET, CCNE1, CCND1, CDK6, MYC, PTEN, PIK3R1, HLA-B, GATA4, GATA6, AURKA, AURKB, ZNF217, CD44, VEGFA, POLE
Comprehensive molecular profiling of lung adenocarcinoma 2014 Nature LUAD EGFR, KRAS, TP53, BRAF, PIK3CA, MET, RIT1, STK11, KEAP1, NF1, RB1, CDKN2A, SETD2, ARID1A, SMARCA4, RBM10, U2AF1, MGA, MYC, ERBB2, ALK, ROS1, RET, NKX2-1, TERT, MDM2, CCNE1, CCND1, CCND3, TERC, MECOM, MAP2K1, NRAS, HRAS, CTNNB1
Somatic ERCC2 mutations correlate with cisplatin sensitivity in muscle-invasive urothelial carcinoma 2014 Cancer Discovery BLCA ERCC2, TP53, RB1, KDM6A, ARID1A, BRCA1, BRCA2
The somatic genomic landscape of chromophobe renal cell carcinoma 2014 Cancer Cell CHRCC, CCRCC TP53, PTEN, TERT, MTOR, NRAS, TSC1, TSC2, FLCN, CDKN2A, PPARGC1A, APOBEC3B, PDCD6, NEK5, SDHB, NDUFS1, PBRM1
Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions 2014 Genome Biology COADREAD, COAD, READ KRAS, NRAS, BRAF, APC, TP53, PIK3CA, SMAD4, SMAD3, MAP2K1, EGFR, CARD11, ETV1, IKZF1, PTK7, RASA1, CDK8, AMER1, FBXW7, CTNNB1, PIK3CD, PIK3CG, PIK3C2G, PIK3R1, PTEN, RUNX1T1
Organoid cultures derived from patients with advanced prostate cancer 2014 Cell PRAD AR, ATRX, CDK12, CDKN2A, CHD1, CHEK2, ERG, FOXA1, FOXP1, KDM4C, KDM4D, KMT2D, MED1, PIK3R1, PTEN, RB1, RYBP, SETD2, SETDB1, SHQ1, SPINK1, SPOP, TMPRSS2, TP53, TSC2
Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations 2014 Cancer Discovery ES STAG2, TP53, CDKN2A, EZH2, BCOR, ZMYM3, EWSR1, FLI1, ERG, ETV1, FEV, TAF15, FUS, SETD2, KMT2D, KMT2C, PRDM9, STAG1, CTCF
Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes 2014 Nature Communications UCS, MXOV TP53, KRAS, ARID1A, ARID1B, KMT2C, KMT2D, SPOP, BAZ1A, PIK3CA, PIK3R1, PTEN, CTNNB1, FBXW7, PPP2R1A, ERBB3, BRCA1, BRCA2, FANCM, MLH1, MSH6
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors 2014 Nature Genetics MPNST EED, SUZ12, NF1, CDKN2A, TP53, EZH1, EZH2, IGF2, FOXN4, PAX2, TLX1
Mutational landscape of aggressive cutaneous squamous cell carcinoma 2014 Clinical Cancer Research CSCC TP53, CDKN2A, NOTCH1, NOTCH2, AJUBA, HRAS, CASP8, FAT1, KMT2C, KMT2D, PARD3, RASA1, RIPK4, RAC1, PIK3CA, NFE2L2, BRAF, NRAS, PTCH1, CCND1, POLE, EGFR, SNX25, EIF2D, RBM46, DCLK1
Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma 2014 New England Journal of Medicine SKCM, MEL CTLA4, BRAF, NRAS, FAM3C, CSMD1
Integrated Genomic Characterization of Papillary Thyroid Carcinoma 2014 Cell THPA BRAF, NRAS, HRAS, KRAS, EIF1AX, PPM1D, CHEK2, TERT, RET, NTRK1, NTRK3, ALK, PPARG, PAX8, ETV6, EML4, SND1, MKRN1, RBPMS, THADA, FGFR2, MET, LTK, PTEN, PIK3CA, AKT1, AKT2, TP53, RB1, NF1, NF2, MEN1, APC, ATM, SPOP, KMT2A, KMT2C, ARID1B, ZFHX3, RAP1GAP, TSHR, FANCA, FGFR3
The genetic landscape of high-risk neuroblastoma 2013 Nature Genetics NBL ALK, PTPN11, ATRX, MYCN, NRAS, CHEK2, BARD1, PINK1, TP53, PALB2, MLH1, PHOX2B, ARID1A, ARID1B
The genomic landscape of hypodiploid acute lymphoblastic leukemia 2013 Nature Genetics BLL TP53, NF1, NRAS, KRAS, FLT3, PTPN11, IKZF2, IKZF3, IKZF1, RB1, CREBBP, EZH2, PAG1, CDKN2A, CDKN2B, MAPK1, CBL, ETV6
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia 2013 Cell CLLSLL TP53, ATM, MYD88, SF3B1, NOTCH1, DDX3X, ZMYM3, FBXW7, XPO1, CHD2, POT1, NRAS, KRAS, BCOR, EGR2, MED12, RIPK1, SAMHD1, ITPKB, H1-4
Exome and whole genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity 2013 Nature Genetics ESCA, GEJ TP53, CDKN2A, SMAD4, PIK3CA, ARID1A, ARID2, SMARCA4, PBRM1, JARID2, ELMO1, DOCK2, RAC1, PAK1, TRIO, TIAM1, VAV2, ECT2, SPART, TLR4, AKAP6, HECW1, AJAP1, NUAK1, KAT6A, KRAS, ERBB2, EGFR, PIK3R1, PTEN, NF1, BRAF, APC, CDH1, AXIN1, CTNNB1, MSH6, MSH3, DNM2, GALNT7, CCND1, CCNE1, CDK6
Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers 2013 Cancer Discovery OCSC, HNSC NOTCH1, CASP8, FAT1, TP53, TP63, HRAS, PIK3CA, BRAF, EGFR, AKT1, CCND1, CDKN2A, MYC, CDKN1A, FHIT, CSMD1, NFIB, JAG1, JAG2, NUMB, MAML1, FADD, BIRC2, BIRC3, IKBKB, LTO1, RPS6KB1, TNK2, PTK2, SRC, LYN, YES1, AURKA, AURKC, TERC, PRKCI
Punctuated Evolution of Prostate Cancer Genomes 2013 Cell PRAD, PRNE TMPRSS2, ERG, ETV1, ETV3, ETV6, SMAD4, SPOP, FOXA1, FOXP1, NKX3-1, NRF1, BRAF, CRKL, MAPK1, MAGI2, GSK3B, FOXO1, PIK3R1, PTEN, TP53, CDKN1B, RB1, CHEK2, CHD1
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia 2013 N Engl J Med AML FLT3, NPM1, DNMT3A, IDH1, IDH2, TP53, RUNX1, CEBPA, TET2, KIT, WT1, PHF6, EZH2, U2AF1, SMC1A, SMC3, RAD21, STAG2, ASXL1, KRAS, NRAS, PTPN11, KDM6A, SF3B1, SRSF2, PML, RARA, CBFB, MYH11, RUNX1T1, KMT2A, MLLT3, MLLT10, NUP98, NSD1, PICALM, BCR, ABL1, KMT2C
Integrated genomic characterization of endometrial carcinoma 2013 Nature UCEC, UEC, USC TP53, PTEN, PIK3CA, PIK3R1, KRAS, CTNNB1, ARID1A, ARID5B, POLE, POLD1, FBXW7, PPP2R1A, MLH1, RPL22, SOX17, ERBB2, MYC, CCNE1, FGFR1, FGFR2, FGFR3, IGF1R, LRP1B, AKT3, CDKN2A, AURKA, CCNB1, ASNS, PGR, FOXA1, RAD50, CTCF, BCL2, BCL2L11, BCL7A, BCL9
The mutational landscape of adenoid cystic carcinoma 2013 Nature Genetics ACYC MYB, NFIB, SMARCA2, SMARCE1, ARID1A, ATRX, CREBBP, EP300, KDM6A, KMT2C, ARID5B, PIK3CA, PTEN, FOXO3, FGF16, FGFR2, FGFR4, IGFBP2, IL17RD, TP53, UHRF1, TXNIP, ATM, BRCA1, NOTCH1, FBXW7, FOXP2, RYR2, RYR3, PTPRG, PTPRH, PTPRJ, PTPRK, HSPG2, IDH1, FAT3, FAT4, MGA
Whole exome sequencing of adenoid cystic carcinoma 2013 The Journal of Clinical Investigation ACYC MYB, NFIB, PIK3CA, ATM, CDKN2A, SF3B1, SUFU, TSC1, CYLD, NOTCH1, NOTCH2, SPEN, FGFR2, ARID1A, ARID1B, ARID5B, CREBBP, EP300, KDM6A, KDM5A, KMT2C, SMARCA2, CHD2, BRD2
Comprehensive molecular characterization of clear cell renal cell carcinoma 2013 Nature CCRCC VHL, PBRM1, SETD2, BAP1, KDM5C, PTEN, MTOR, TP53, ARID1A, SMARCA4, HIF1A, CDKN2A, MYC, MDM4, JAK2, PRKCI, MECOM, TFE3, SFPQ, EGFR, GRB10, TSC2, SQSTM1, RACK1, UQCRH, FASN, G6PD, CTNNB1, TGFBR2, NEGR1, QKI, CADM2, PTPRD, NRXN3
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma 2013 Nature Genetics PAST, GB, DMG FGFR1, NTRK2, BRAF, KRAS, PTPN11, NF1, H3-3A, FGF2, KIAA1549, FAM131B, RNF130, CLCN6, MKRN1, GNAI1, QKI, NACC2, TP53, FGFR2, FGFR3, RAF1, NTRK1, NTRK3, TACC1, TACC3, FLT3
Prevalence and Co-Occurrence of Actionable Genomic Alterations in High-Grade Bladder Cancer 2013 Journal of Clinical Oncology BLCA TP53, RB1, FGFR3, FGFR1, PIK3CA, ERBB2, MDM2, CDKN2A, CDKN2B, CCND1, CCNE1, E2F3, KRAS, BRAF, HRAS, NF1, MET, RAF1, AKT1, PTEN, TSC1, MTOR
New cast for a new era: preclinical cancer drug development revisited 2013 The Journal of Clinical Investigation LUAD, PAAD, APLPMLRARA, NSCLC KRAS, STK11, SMO, TP53
The Somatic Genomic Landscape of Glioblastoma 2013 Cell GBM EGFR, PDGFRA, PTEN, TP53, PIK3CA, PIK3R1, NF1, RB1, IDH1, LZTR1, SPTA1, ATRX, GABRA6, KEL, BRAF, TERT, QKI, LRP1B, NPAS3, LSAMP, SMYD3, MET, FGFR1, FGFR2, FGFR3, TACC3, MDM2, MDM4, CDK4, CDK6, CDKN2A, CCND1, CCND2, CCNE2, SOX2, MYC, MYCN, MGMT, IDH2, H3-3A, SEC61G, LANCL2, VOPP1, BRIP1, CPM, PRIM2, BCL11A
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation 2013 Nature Genetics BLCA STAG2, ESPL1, FGFR3, TACC3, NIPBL, SMC1A, SMC3, TP53, HRAS, KRAS, PIK3CA, RB1, TSC1, KDM6A, UTY, ARID1A, ARID4A, KMT2A, KMT2C, KMT2E, EP300, EP400, CREBBP, NCOR1, CHD6, SMARCA4, KDM5A, KDM5B, ERCC2, TRRAP, FAT4, MDM2, MYC, E2F1, E2F3, CCND1, CCNE1, ERBB2, CEBPA, MUC1, TRIO, DHFR, CDKN2A, CDKN2B, BRCA1, BRCA2, ATM, ATR, BUB1
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma 2013 Proceedings of the National Academy of Sciences USA MCL ATM, CCND1, TP53, NSD2, KMT2D, BIRC3, MEF2B, TLR2, NOTCH1, NOTCH2, SOX11, UBR5, B2M, CDKN2A
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas 2013 Nature Genetics IHCH, GBC BAP1, ARID1A, PBRM1, IDH1, IDH2, FGFR2, TP53, KRAS, NRAS, PIK3CA, PTEN, PIK3C2A, PIK3C2G, AKT1, CDKN2A, SMAD4, CTNNB1, TGFBR2, KMT2C
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2 2013 New England Journal of Medicine MPN, ET, PV, MF, MPNU, MDS, CMML, ACML, AML CALR, JAK2, MPL, TET2, DNMT3A, ASXL1, EZH2, IDH1, IDH2, U2AF1, SF3B1, SRSF2, CBL, NFE2, SH2B3, CHEK2
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing 2012 Proceedings of the National Academy of Sciences DLBCLNOS MYD88, CARD11, EZH2, CREBBP, CD79B, TP53, KMT2D, TNFRSF14, BTG1, MEF2B, GNA13, BCL2, KRAS, BRAF, NOTCH1, PIM1, ACTB, P2RY8, CCND3, SOCS1, B2M, HLA-A, STAT3, SGK1, STAT6, CD58, NFKBIA, SYK, ETV6, TBL1XR1
The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity 2012 Nature MEL, PCM, ES, NBL BRAF, NRAS, KRAS, EGFR, ERBB2, MET, ALK, MDM2, AHR, SLFN11, NQO1, IGF1R, IGF1, PTEN, TP53, HGF, EXT2, MITF, SOX10, CYP1A1, TOP1, SPRY2, PTPN5
The clonal and mutational evolution spectrum of primary triple negative breast cancers 2012 Nature BRCA TP53, PIK3CA, PTEN, RB1, EGFR, BRCA2, BRAF, NRAS, ERBB2, ERBB3, KRAS, IDH1, ETV6, PRKN, USH2A, MYO3A, ATR, UBR5, COL6A3, PIK3R1, ATM, SYNE1, SYNE2, PRPS2, NR3C1, PRKCZ, GH1
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups 2012 Nature BRCA PPP2R2A, MTAP, MAP2K4, ZNF703, PTEN, MYC, CCND1, MDM2, ERBB2, CCNE1, MDM4, CDK4, NCOR1, PAK1, RSF1, EMSY, IGF1R, KRAS, EGFR, CDKN2A, CDKN2B, BRCA2, RB1, ATM, SMAD4, TP53, AURKB, BUB1, FOXM1, TTK, CHEK1
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer 2012 Nature Genetics PRAD SPOP, FOXA1, MED12, TP53, PTEN, PIK3CA, CDKN1B, CHD1, TMPRSS2, ERG, AR, NKX3-1, MSH6, THSD7B, SCN11A, ZNF595, FOXO3, PRDM1
Melanoma genome sequencing reveals frequent PREX2 mutations 2012 Nature SKCM, MEL PREX2, BRAF, NRAS, PTEN, KIT, ETV1, MITF, MAGI2, FHIT, MACROD2, CSMD1, RBFOX1
The landscape of cancer genes and mutational processes in breast cancer 2012 Nature BRCA TP53, PIK3CA, AKT1, AKT2, ERBB2, MYC, FGFR1, ZNF703, GATA3, CCND1, CDH1, PTEN, RB1, BRCA1, MAP3K1, MAP2K4, MAP3K13, NCOR1, SMARCD1, ARID1B, CDKN1B, CASP8, TBX3, KRAS, NF1, APC, ARID1A, ARID2, ASXL1, BAP1, SETD2, SF3B1, SMAD4, STK11, MDM2
Sequence analysis of mutations and translocations across breast cancer subtypes 2012 Nature BRCA PIK3CA, TP53, AKT1, GATA3, MAP3K1, CBFB, RUNX1, ERBB2, AKT3, MAGI3, PTEN
Novel mutations target distinct subgroups of medulloblastoma 2012 Nature MBL KDM6A, EZH2, DDX3X, PIK3CA, CTNNB1, SMARCA4, CREBBP, CHD7, ZMYM3, CDH1, MYC, MYCN, OTX2, TP53, PTCH1, PTEN, APC, SUFU, KMT2D, TRRAP, MED13
The Mutational Landscape of Lethal Castrate Resistant Prostate Cancer 2012 Nature PRAD AR, TP53, PTEN, RB1, CHD1, FOXA1, KMT2D, CDK12, ERG, TMPRSS2, ETS2, ETV3, ETV1, ETV5, KDM6A, ASXL1, ASH2L, KMT2A, ZFHX3, APC, OR5L1, PRKDC, EZH2, SPINK1, KLK3
CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set 2012 Cancer Research COAD ABCB1, EGFR, CDH1, MYC, TOP1, CHEK2, ZEB1, RNF43
Comprehensive molecular characterization of human colon and rectal cancer 2012 Nature COADREAD APC, TP53, KRAS, PIK3CA, FBXW7, SMAD4, TCF7L2, NRAS, CTNNB1, SMAD2, AMER1, SOX9, ARID1A, BRAF, ERBB2, ERBB3, IGF2, PTEN, PIK3R1, MLH1, MSH2, MSH3, MSH6, PMS2, POLE, TGFBR2, ACVR2A, MYC, NAV2, TCF7L1, IRS2
A Landscape of Driver Mutations in Melanoma 2012 Cell MEL, SKCM BRAF, NRAS, PTEN, TP53, CDKN2A, MAP2K1, PPP6C, RAC1, SNX31, TACC1, ARID2, NF1, CTNNB1, PIK3CA, EZH2, IDH1, GNA11, KIT, HRAS, RB1, CDK4, CCND1, MITF, TERT, ARID1A, ARID1B, SMARCA4, FBXW7
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations 2012 Nature MBL DDX3X, CTNNB1, PTCH1, KMT2D, KMT2C, SMARCA4, TP53, GPS2, BCOR, LDB1, KDM6A, CTDNEP1, SUFU, CSNK2B, NCOR2
Dissecting the genomic complexity underlying medulloblastoma 2012 Nature MBL CTNNB1, DDX3X, PTCH1, SMARCA4, KMT2D, TP53, KDM6A, CTDNEP1, MYCN, SMO, BCOR, TBR1, EOMES, ERBB4, DNAJB6, SHH
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma 2012 Nature Genetics MEL, SKCM, UM RAC1, BRAF, NRAS, PPP6C, NF1, TP53, ARID2, PTEN, CDKN2A, DCC, PTPRK, PTPRD, PAK1, CDK4, CCND1, RICTOR, BAP1
Recurrent R-spondin fusions in colon cancer 2012 Nature COAD, COADREAD RSPO2, RSPO3, APC, KRAS, TP53, SMAD4, FBXW7, PIK3CA, ATM, TCF7L2, TET2, TET3, ERBB3, IGF2, MYC, BRAF, CTNNB1, PTEN
Integrative genome analyses identify key somatic driver mutations of small cell lung cancer 2012 Nature Genetics SCLC TP53, RB1, CREBBP, EP300, KMT2A, PTEN, SLIT2, EPHA7, FGFR1, MYCL, MYCN, MYC, SOX2, CCNE1, NFIB, COBL, PIK3CA
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer 2012 Nature Genetics SCLC SOX2, TP53, RB1, MYCL, PIK3CA, PTEN, MYC, KIT, NOTCH1, EP300, CDKN2A
Comprehensive genomic characterization of squamous cell lung cancers 2012 Nature LUSC TP53, CDKN2A, PTEN, PIK3CA, KEAP1, KMT2D, HLA-A, NFE2L2, NOTCH1, RB1, EGFR, KRAS, SOX2, TP63, FGFR1, NSD3, PDGFRA, KIT, CCND1, MYC, CDK6, MDM2, BCL2L1, FOXP1, NF1, CUL3, NOTCH2, ASCL4, DDR2, HRAS, FBXW7, SMARCA4, SMAD4, APC, TSC1, BRAF, TNFAIP3, CREBBP, AMER1, AKT3
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing 2012 Cell LUAD TP53, KRAS, EGFR, STK11, KEAP1, NF1, BRAF, SMAD4, U2AF1, RBM10, ARID1A, SETD2, BRD3, SMARCA4, PIK3CA, CTNNB1, FGFR3, ATM, CBL, PTEN, FBXW7, RB1, CDKN2A, NKX2-1, TERT, MYC, ERBB2, SIK2
Comprehensive molecular portraits of human breast tumors 2012 Nature BRCA, HGSOC TP53, PIK3CA, GATA3, MAP3K1, MAP2K4, CDH1, PTEN, AKT1, RB1, ERBB2, EGFR, BRCA1, BRCA2, PIK3R1, NF1, SF3B1, TBX3, RUNX1, CBFB, FOXA1, MYC, CCND1, CCNE1, INPP4B, KRAS, BRAF, MDM2, ATM, FGFR1, FGFR2, FGFR4, KIT, MET, PDGFRA, IGF1R, CDK4
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes 2012 Nature PAAD KRAS, TP53, CDKN2A, SMAD4, KMT2C, TGFBR2, ARID1A, SF3B1, EPC1, ARID2, ATM, ZIM2, MAP2K4, NALCN, SLC16A4, MAGEA6, SLIT2, ROBO1, ROBO2, ROBO3, SEMA3A, SEMA3E, PLXNA1
DAXX/ATRX, MEN1 and mTOR Pathway Genes are Frequently Altered in Pancreatic Neuroendocrine Tumors 2011 Science PANET MEN1, DAXX, ATRX, PTEN, TSC2, PIK3CA, TP53, KRAS
Integrated Genomic Analyses of Ovarian Carcinoma 2011 Nature HGSOC TP53, BRCA1, BRCA2, NF1, RB1, CDK12, CCNE1, MYC, MECOM, KRAS, NRAS, BRAF, PIK3CA, PTEN, FOXM1, CSMD3, FAT3, GABRA6, CREBBP, RAD51C
Frequent mutation of histone modifying genes in non-Hodgkin lymphoma 2011 Nature DLBCLNOS, FL KMT2D, MEF2B, EZH2, CREBBP, EP300, GNA13, SGK1, TP53, MYD88, CARD11, CD79B, BCL2, TNFAIP3, TNFRSF14, BTG1, B2M, FOXO1, CCND3, BCL10
The Mutational Landscape of Head and Neck Squamous Cell Carcinoma 2011 Science HNSC TP53, CDKN2A, PTEN, PIK3CA, HRAS, NOTCH1, NOTCH2, NOTCH3, IRF6, TP63, CCND1, EGFR, ERBB2, CCNE1, MYC, SYNE1, SYNE2, CASP8, DDX3X, EZH2, PRDM9, CDH1, KMT2D, DICER1
Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 2011 Science HNSC NOTCH1, TP53, CDKN2A, PIK3CA, HRAS, FBXW7, EGFR, CCND1
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways 2011 Proceedings of the National Academy of Sciences IPMN, MCN, SPN, PAAD VHL, RNF43, CTNNB1, KRAS, GNAS, TP53, APC, TBC1D3, MUC4
Integrative genomic profiling of human prostate cancer 2010 Cancer Cell PRAD NCOA2, ERG, TMPRSS2, PTEN, RB1, TP53, AR, MYC, PIK3CA, PIK3R1, KRAS, BRAF, FOXP1, RYBP, SHQ1, NKX3-1, INPP4B, ETV6, CDKN1B, NCOR2, MSH6, IDH2
Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapy 2010 Nature Genetics DDLS, MRLS, PLLS, LMS, GIST, MFS, SYNS, MPNST TP53, NF1, PIK3CA, CDK4, YEATS4, MDM2, KIT, PDGFRA, CDH1, ERBB4, PTEN, RB1, AKT1
Phase 3 Randomized Trial on Larynx Preservation Comparing Sequential vs Alternating Chemotherapy and Radiotherapy 2009 Journal of the National Cancer Institute HNSC, LXSC, HPHSC
Comprehensive genomic characterization defines human glioblastoma genes and core pathways 2008   GB EGFR, ERBB2, NF1, TP53, PIK3R1, PIK3CA, PTEN, RB1, CDKN2A, CDKN2B, CDK4, CDK6, MDM2, MDM4, MLH1, MSH2, MSH6, PMS2, MGMT
Somatic mutations affect key pathways in lung adenocarcinoma 2008 Nature LUAD TP53, KRAS, EGFR, STK11, CDKN2A, NF1, ATM, RB1, APC, LRP1B, PTPRD, ERBB4, EPHA3, KDR, NTRK1, NTRK2, NTRK3, ERBB2, ERBB3, FGFR4, NRAS, PTEN, BRAF, PIK3CA, AKT1, CTNNB1, PRKDC, SMG1, PDGFRA, EPHA7, EPHB1, MDM2, TERT, CDK4, CDK6, CCND1, CCNE1, CDKN2B, TSC1, TSC2, SMAD2, SMAD4, GSK3B, HCK, PIK3C3, INHBA, FLT4
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