Anaplastic Large-Cell Lymphoma ALK Positive (ALCLALKP)

Overview

ALK-positive Anaplastic Large-Cell Lymphoma, a subtype of ALCL within Mature T and NK Neoplasms.

Cohorts in the corpus

• mtnn_msk_2022: ALK+ ALCL comprised 5% (approximately n=6) of the MSK nodal PTCL cohort PMID:37078708.

Recurrent alterations

• Small absolute numbers limit subgroup inference; analyzed within the PTCL cohort where TP53 and CDKN2A alterations carried prognostic weight PMID:37078708.

Subtypes

• See parent ALCL.

Therapeutic landscape

• Curative-intent CHOP-based chemotherapy including brentuximab-vedotin-containing regimens (BV-CH(E)P) PMID:37078708.

Sources

• PMID:37078708

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