Adult T-Cell Leukemia/Lymphoma (ATLL)
Overview
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive mature T-cell malignancy caused by HTLV-1 infection. In OncoTree it sits under Mature T and NK Neoplasms (MTNN). RHOA gain-of-function mutations (C16R, A161P) are characteristic somatic drivers distinguishing ATLL from the closely related AITL/PTCL group where loss-of-function G17V predominates.
Cohorts in the corpus
- No ATLL-specific cohort pages currently linked.
Recurrent alterations
- RHOA C16R (gain-of-function; accelerates GTP/GDP cycling) and A161P (gain-of-function; uniquely activates Slt2/MAPK in yeast and shows the most CalMorph features altered) are the predominant RHOA hotspots in ATLL, contrasting with the dominant-negative G17V seen in AITL; functional yeast modelling separated GOF (C16R, A161P) from LOF (R5Q, G17V) into distinct morphological classes PMID:24816253.
Subtypes
- WHO subtypes include acute, lymphomatous, chronic, and smoldering ATLL.
Therapeutic landscape
- No drug pages currently linked for ATLL in this corpus.
Sources
This page was processed by entity-page-writer on 2026-05-11.