Burkitt Lymphoma (BL)

Overview

Burkitt lymphoma (BL) is a highly aggressive mature B-cell malignancy typically driven by MYC translocation (t(8;14)); it sits under Mature B-Cell Neoplasms (MBN) in OncoTree. EBV association is prominent in the endemic (African) variant. RHOA R5Q is an incidental recurrent mutation observed in BL alongside its more characteristic occurrence in diffuse-type gastric carcinoma.

Cohorts in the corpus

• No BL-specific cohort pages currently linked.

Recurrent alterations

• RHOA R5Q (attenuated-output loss-of-function) is recurrent in Burkitt lymphoma (BL) and diffuse-type gastric carcinoma; in yeast modelling it complements RHO1 loss and clusters morphologically near wild-type, indicating a modest perturbation relative to stronger GOF/LOF RHOA alleles PMID:24816253.
• A Burkitt lymphoma cell line (BJAB) was included in the six-cell-line genome-wide CRISPR screen (GeCKO v2, ~120k sgRNAs) alongside DLBCL lines to identify essential oncogenic dependencies across B-cell lymphoma types PMID:28985567

Subtypes

• Endemic (EBV-associated), sporadic, and immunodeficiency-associated variants.

Therapeutic landscape

• No drug pages currently linked for BL in this corpus.

Sources

• PMID:24816253

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