Chronic Myelomonocytic Leukemia (CMML)

Overview

Chronic Myelomonocytic Leukemia (CMML) is a clonal hematopoietic neoplasm with features of both myelodysplastic and myeloproliferative disorders. It sits under the MDS/MPN parent in OncoTree. CALR mutations have been rarely detected in CMML, in contrast to their strong association with BCR-ABL1-negative MPNs.

Cohorts in the corpus

Recurrent alterations

  • In a large follow-up Sanger sequencing screen of 1,345 hematologic cancers, only 1/33 CMML cases carried a CALR exon 9 frameshift indel, contrasting with 70-84% prevalence in JAK2/MPL-negative MPN. PMID:24325359

Subtypes

  • No molecular subtypes defined in the current corpus.

Therapeutic landscape

  • No CMML-specific drug data in the current corpus.

Sources

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