Diffuse Type Stomach Adenocarcinoma (DSTAD)
Overview
Diffuse-type stomach adenocarcinoma (DSTAD) is a histologically distinct subtype of gastric adenocarcinoma characterised by poorly cohesive, signet-ring cells without gland formation; it sits under STAD in OncoTree. RHOA somatic mutations (e.g., R5Q, G17V, C16R) are enriched in diffuse-type GC relative to intestinal-type, and CDH1 loss (germline or somatic) defines the hereditary diffuse gastric cancer spectrum.
Cohorts in the corpus
- No DSTAD-specific cohort pages currently linked.
Recurrent alterations
- RHOA R5Q (attenuated-output loss-of-function; reduces RhoA activation) is recurrent in diffuse-type gastric carcinoma (DSTAD) and Burkitt lymphoma; functional yeast modelling shows it complements RHO1 and clusters morphologically close to wild-type PMID:24816253.
- Diffuse-type stomach adenocarcinoma was represented within the MSK EGC cohort; the GS molecular subtype (genomically stable, 34%) was enriched for diffuse histology and CDH1 mutations (20% vs 7% in CIN, P=0.01), consistent with the role of E-cadherin loss in diffuse gastric carcinogenesis PMID:29122777
Subtypes
- Genomically Stable (GS) TCGA subtype is enriched in diffuse-type GC with RHOA and CDH1 alterations.
Therapeutic landscape
- No drug pages currently linked for DSTAD in this corpus.
Sources
This page was processed by entity-page-writer on 2026-05-11. - PMID:29122777
This page was processed by wiki-cli on 2026-05-15.