Kidney Chromophobe / KICH (TCGA)
Overview
KICH is the TCGA cohort identifier for kidney chromophobe renal cell carcinoma. The closest OncoTree equivalent is CHRCC (Chromophobe Renal Cell Carcinoma). This page covers findings specifically attributed to the TCGA KICH cohort in the corpus. KICH is characterized by low tumor purity and large sample-to-sample variability in mutation burden.
Cohorts in the corpus
- TCGA KICH cohort: included as one of 33 cancer types in the MC3 pan-cancer mutation-calling project and the TCGA fusion landscape study; subset of the PanCancer Atlas (kich_tcga_pan_can_atlas_2018).
Recurrent alterations
- MC3 pan-cancer mutation-calling project (10,510 TCGA tumor/normal pairs) identified KICH alongside THYM, PAAD, and UVM as showing the largest sample-to-sample variability in mutations per sample, attributable to low tumor purity PMID:29596782.
- Pan-cancer fusion study (9,624 TCGA samples) found KICH has a median of 0 fusions per sample; fusion neoantigen burden was lowest in KICH (mean 0.33 predicted neoantigens per fusion) PMID:29617662.
Subtypes
Therapeutic landscape
No drug-specific findings for KICH reported in the current corpus.
Sources
- PMID:29596782 — MC3 multi-center mutation calling (Ellrott et al., 2018)
- PMID:29617662 — Pan-cancer fusion landscape (Gao et al., 2018)
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