Kidney Renal Clear Cell Carcinoma / KIRC (TCGA)
Overview
KIRC is the TCGA cohort identifier for kidney renal clear cell carcinoma. The closest OncoTree equivalent is CCRCC (Renal Clear Cell Carcinoma). This page covers findings specifically attributed to the TCGA KIRC cohort in the corpus. KIRC has been used as a benchmark cancer type for somatic variant calling quality assessment in pan-cancer projects.
Cohorts in the corpus
- TCGA KIRC cohort: included as one of 33 cancer types in the MC3 pan-cancer mutation-calling project and the TCGA fusion landscape study; subset of the PanCancer Atlas (kirc_tcga_pan_can_atlas_2018).
Recurrent alterations
- MC3 pan-cancer mutation-calling project used KIRC as a benchmark: running MutSig2CV and MuSiC2 on PASS variants yielded 10 SMGs each (TP53, PTEN, VHL, SETD2, PBRM1, BAP1, MTOR, PIK3CA, ATM, ELOC); the unfiltered controlled MAF inflated these to 1,203 and 321 respectively, demonstrating the critical importance of filtering PMID:29596782.
- Pan-cancer fusion study (9,624 TCGA samples) found KIRC has a median of 0 fusions per sample PMID:29617662.
Subtypes
Therapeutic landscape
No drug-specific findings for KIRC reported in the current corpus beyond the general significance of VHL and mTOR pathway mutations.
Sources
- PMID:29596782 — MC3 multi-center mutation calling (Ellrott et al., 2018)
- PMID:29617662 — Pan-cancer fusion landscape (Gao et al., 2018)
This page was processed by crosslinker on 2026-05-15.