Kidney Renal Papillary Cell Carcinoma / KIRP (TCGA)

Overview

KIRP is the TCGA cohort identifier for kidney renal papillary cell carcinoma. The closest OncoTree equivalent is PRCC (Papillary Renal Cell Carcinoma). This page covers findings specifically attributed to the TCGA KIRP cohort in the corpus.

Cohorts in the corpus

• TCGA KIRP cohort: included as one of 33 cancer types in the fusion landscape study; subset of the PanCancer Atlas (kirp_tcga_pan_can_atlas_2018).

Recurrent alterations

• Pan-cancer fusion study (9,624 TCGA samples) found KIRP has a median of 0 fusions per sample; 6% to 28% (highest in KIRP) of kinase-partner fusions were over-expression outliers, suggesting promoter-swap mechanisms are relatively frequent in papillary RCC PMID:29617662.

Subtypes

• Papillary RCC (type 1 and type 2) is molecularly distinct from clear cell and chromophobe RCC; KIRP (TCGA) corresponds approximately to OncoTree PRCC.

Therapeutic landscape

No drug-specific findings for KIRP reported in the current corpus.

Sources

• PMID:29617662 — Pan-cancer fusion landscape (Gao et al., 2018)

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