Large Cell Neuroendocrine Carcinoma (LUNE)
Overview
Large Cell Neuroendocrine Carcinoma (LUNE) is a high-grade, poorly differentiated neuroendocrine carcinoma of the lung under LNET in OncoTree. It is characterized by large cells with neuroendocrine morphology, high mitotic rate, and necrosis.
Cohorts in the corpus
- pog570_bcgsc_2020 — included within 7 metastatic pulmonary NEN cases in the 28-patient metastatic NEN WGTA cohort at BC Cancer POG. PMID:24326773
Recurrent alterations
- Metastatic pulmonary NENs including high-grade cases (LUNE) in the POG cohort showed recurrent MEN1, RB1, and TP53 alterations on whole-genome and transcriptome analysis; high-grade cases potentially contributed to transcriptome Cluster B (MYC-enriched, high-grade). Median TMB 2.19 mut/Mb across the 28-patient NEN cohort. PMID:24326773
Subtypes
- Poorly differentiated large cell NEC vs. NET-G3 histology.
Therapeutic landscape
- No LUNE-specific drug data in the current corpus.
Sources
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