Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma (MEITL)
Overview
MEITL is a Mature T and NK Neoplasm (parent MTNN).
Cohorts in the corpus
- mtnn_msk_2022: 3% of the 132-patient nodal PTCL cohort (n=4) at MSK were MEITL PMID:37078708.
Recurrent alterations
- CDKN2A aberrancies in 3/4 (75%) of MEITL cases, a notable enrichment compared with the broader cohort PMID:37078708.
- CDKN2A deletions (n=9 across entire cohort) correlated with markedly inferior OS (HR 12.1; 95% CI 2.8–52.0; P<.001; median OS 17.6 vs 56.7 months) PMID:37078708.
Subtypes
- Not further subdivided in this corpus.
Therapeutic landscape
- Curative-intent CHOP-based chemotherapy; CDKN2A-deleted MEITL represents a very high-risk subset PMID:37078708.
Sources
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