Mixed Germ Cell Tumor (MGCT)

Overview

Mixed Germ Cell Tumor is a Non-Seminomatous Germ Cell Tumor (parent NSGCT).

Cohorts in the corpus

• makeanimpact_ccr_2023: 54 male germ cell tumor patients were profiled as part of the Make-an-IMPACT direct-to-patient outreach cohort on MSK-IMPACT PMID:36862133.

Recurrent alterations

• Not specifically characterized in this corpus beyond cohort enrollment counts PMID:36862133.
• 49 mixed GCTs (teratoma-containing) in the MSK-IMPACT cohort (Bagrodia et al., N=180); TP53/MDM2 alterations independently predicted shorter PFS (HR 1.83, P=.016) after adjusting for IGCCCG risk; 55% of cisplatin-resistant GCTs harbored actionable alterations PMID:27646943.

Subtypes

• Not called out in the corpus.

Therapeutic landscape

• Not specifically reported in this corpus.

Sources

• PMID:36862133

This page was processed by crosslinker on 2026-04-08. - PMID:27646943 — Bagrodia et al. 2016 (JCO). 49 MGCT in MSK germ cell tumor cohort; TP53/MDM2 alterations independently predicted shorter PFS; 55% of cisplatin-resistant GCTs had actionable alterations.

This page was processed by entity-page-writer on 2026-05-15.