Miscellaneous Neuroepithelial Tumor (MNET)

Overview

Miscellaneous Neuroepithelial Tumor (MNET) sits under the BRAIN parent in OncoTree. Note: In the 24326773 corpus reference, MNET is used alongside HGONEC to classify an ovarian mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN); the paper-compiler assigned both MNET and HGONEC codes to that case. The canonical OncoTree MNET code covers miscellaneous neuroepithelial tumors of the brain/CNS.

Cohorts in the corpus

  • pog570_bcgsc_2020 — 1 ovarian MiNEN case (PN19) annotated with MNET in the paper-compiler output within 28-patient metastatic NEN WGTA cohort. PMID:24326773

Recurrent alterations

  • The ovarian MiNEN case (PN19) annotated MNET/HGONEC carried MYC amplification, KRAS gain-of-function mutation, SMAD4 loss, TP53 loss, and RB1 loss. Its transcriptome clustered with TCGA colorectal adenocarcinomas. Median TMB 2.19 mut/Mb across the 28-patient NEN cohort. PMID:24326773

Subtypes

  • MiNEN variant with adenocarcinoma and neuroendocrine components.

Therapeutic landscape

  • Immune-checkpoint inhibitors and DLL3 inhibitors flagged as potential options based on expression data (PN19). PMID:24326773

Sources

This page was processed by crosslinker on 2026-05-09.