Myeloproliferative Neoplasms, Unclassifiable (MPNU)

Overview

Myeloproliferative Neoplasms, Unclassifiable (MPNU) is an OncoTree subtype under MPN for MPN cases that do not meet diagnostic criteria for ET, PV, or primary myelofibrosis. These cases can carry the same driver mutations (JAK2, CALR, MPL) as other MPNs.

Cohorts in the corpus

Recurrent alterations

  • 2 unclassifiable MPN patients were included in the CALR discovery cohort; CALR, JAK2, and MPL mutations were assessed across all 151 patients (48 PV, 62 ET, 39 MF, 2 MPNU) with 97% carrying one of these three drivers in mutually exclusive fashion. PMID:24325359

Subtypes

  • By definition, cannot be classified as ET, PV, or PMF.

Therapeutic landscape

  • No MPNU-specific drug data in the current corpus.

Sources

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