Neuroendocrine Tumor, NOS (NETNOS)

Overview

Neuroendocrine Tumor, NOS (NETNOS) is a catch-all OncoTree code under Cancer of Unknown Primary (CUP) for neuroendocrine tumors where the primary anatomical site cannot be determined. In the 24326773 corpus reference, one patient had an unknown primary NEN.

Cohorts in the corpus

Recurrent alterations

  • The NEN of unknown primary in the POG cohort was profiled by whole-genome and transcriptome analysis; the 1,553-gene tumour-type discriminator panel classified 82% of NENs (23/28) with known NENs from external datasets — including the unknown-primary case. Actionable alterations were identified; median TMB 2.19 mut/Mb across the 28-patient NEN cohort. PMID:24326773

Subtypes

  • Unknown primary; histologic grade (well-differentiated vs. poorly differentiated) not specified for this case.

Therapeutic landscape

  • Transcriptome-guided actionable therapy identified for the unknown-primary NEN case via the POG WGTA approach. PMID:24326773

Sources

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