Ovarian Epithelial Tumor (OV)

Overview

OV is the OncoTree umbrella code for epithelial tumors of the ovary and fallopian tube. The dominant clinical subtype is high-grade serous ovarian cancer (HGSOC), which originates from the fallopian tube fimbria and is characterized by near-universal TP53 mutation, frequent homologous-recombination deficiency, and chromosomal instability.

Cohorts in the corpus

Recurrent alterations

  • TP53, BRCA1, BRCA2, CCNE1 — see HGSOC for the canonical subtype profile.
  • Pan-cancer fusion study (9,624 TCGA samples) included OV as one of 33 TCGA cancer types; ovarian tumors were included in the gynecological cluster analyzed for arm-level aneuploidy; druggable fusions covered 6% of pan-can samples PMID:29617662

Subtypes

  • HGSOC — high-grade serous (the dominant subtype; tracked as a separate page).
  • Low-grade serous, endometrioid, clear-cell, and mucinous subtypes are clinically distinct but not directly profiled in the current corpus.

Therapeutic landscape

Sources

  • PMID:39386723 — HGSOC precursor-to-cancer spatial atlas (Gray Foundation / GeoMx).

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