Spindle Cell Rhabdomyosarcoma (SCRMS)
Overview
Spindle Cell Rhabdomyosarcoma is a Soft Tissue Sarcoma subtype of RMS, including spindle cell/sclerosing variants often defined by MYOD1 mutations.
Cohorts in the corpus
- rms_msk_2023: 2 MYOD1-mutant spindle cell/sclerosing RMS cases within the 61-patient extremity RMS cohort PMID:37315267.
Recurrent alterations
- MYOD1 activating mutation defines the 2 spindle cell/sclerosing RMS cases in the cohort PMID:37315267.
Subtypes
- Defined by MYOD1 mutation rather than FOXO1 fusion status PMID:37315267.
Therapeutic landscape
- Treated under sequential COG/institutional RMS protocols at MSKCC; small sample limits subtype-specific inference PMID:37315267.
Sources
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