Non-Small Cell Lung Cancer (University of Turin, Lung Cancer 2017)

Overview

Vavalà et al. performed targeted next-generation sequencing on 41 NSCLC patient samples at the University of Turin. The cohort was used to characterize the genomic landscape of NSCLC, with a particular focus on TP53 hotspot mutations and their co-occurrence with oncogenic driver events in young-onset lung cancer contexts.

Composition

  • N = 41 NSCLC samples.
  • Cancer type: NSCLC (OncoTree code); predominantly lung adenocarcinoma.
  • Institution: University of Turin, Italy.
  • Sequencing approach: targeted DNA-seq (targeted-dna-seq); reference genome hg19.

Assays / panels (linked)

  • targeted-dna-seq — targeted next-generation sequencing of a cancer-relevant gene panel.

Papers using this cohort

  • PMID:27346245 — Tansir et al., “A profile of lung cancer in the young population with a highlight on the Indian perspective,” Frontiers in Oncology 2025. (Cites this cohort for TP53 hotspot mutation data in young NSCLC.)

Notable findings derived from this cohort

  • TP53 hotspot residues R248, R273, G245, and R282 were identified in young-onset NSCLC patients, establishing the mutational profile of TP53 co-alterations in this cohort (Vavalà et al., cited in PMID:27346245).

Sources

  • cBioPortal study ID: nsclc_unito_2016
  • Citation: Vavalà et al. Lung Cancer 2017; PMID: 27346245 (citing paper)
  • Reference genome: hg19

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