Radiation-Associated Sarcomas (MSK, 2023)

Overview

The sarcoma_msk_2023 dataset is a Memorial Sloan Kettering Cancer Center (MSK) cohort of 82 radiation-associated (RT) sarcoma patients spanning four histotypes: angiosarcoma, malignant peripheral nerve sheath tumor, undifferentiated pleomorphic sarcoma, and osteosarcoma. The study compared the genomic landscapes of RT-sarcomas with matched sporadic sarcoma controls (548 total sporadic cases) PMID:37350195.

Composition

Assays / panels (linked)

Papers using this cohort

  • PMID:37350195 — Dermawan JK et al., “Distinct genomic landscapes in radiation-associated angiosarcoma compared with other radiation-associated sarcoma histologies,” J Pathol 2023.

Notable findings derived from this cohort

  • RT-AS has a genomically distinct landscape from other RT-sarcoma histotypes, dominated by MYC amplification (75%), while other RT-sarcomas are driven by TP53 and CDKN2A/CDKN2B loss PMID:37350195.
  • RT-MPNST showed the highest FGA (51%) and near-universal CDKN2A/B deletions (92%) PMID:37350195.
  • Each RT-sarcoma histotype harbored distinct mutations and copy number alterations, supporting histotype-specific therapeutic approaches PMID:37350195.
  • MYC-amplified RT-AS had significantly shorter latency from radiation to sarcoma diagnosis than non-MYC-amplified cases (P = 0.0083) PMID:37350195.
  • Predominant mutational signatures across all four RT-sarcoma histotypes were associated with errors in DNA repair and replication PMID:37350195.

Sources

This page was processed by crosslinker on 2026-04-10.