TCIA H&N2 HNSCC (VU University Medical Center)

Overview

The H&N2 collection comprises 95 head and neck squamous cell carcinoma (HNSC) patients treated at VU University Medical Center (Amsterdam, Netherlands). It served as the second independent HNSCC validation cohort in Aerts et al. 2014. CT scans and survival data are hosted on TCIA. PMID:24892406

Composition

  • Cancer type: HNSC, n=95.
  • Modality: CT; head-and-neck immobilisation protocol.
  • Clinical data: treatment records, TNM staging, HPV status (subset), overall survival.
  • Role in Aerts 2014: second cross-disease validation of the NSCLC-derived four-feature radiomic signature. PMID:24892406

Assays / panels (linked)

  • CT radiomics — 440-feature library applied with Lung1-derived feature definitions.

Papers using this cohort

  • PMID:24892406 — Aerts et al. 2014, Nature Communications: H&N2 used as second HNSCC validation; the four-feature signature achieved concordance index 0.69 (P=3.53 × 10⁻⁶, Wilcoxon).

Notable findings derived from this cohort

  • 186 / 440 radiomic features (42%) were significantly prognostic in H&N2 at FDR 10% using Lung1-derived median thresholds. PMID:24892406
  • Signature outperformed TNM in H&N2; signature + TNM significantly improved over TNM alone. PMID:24892406
  • Signature retained prognostic performance in the HPV-negative subgroup (CI=0.66, n=130, combined H&N1+H&N2 76% of patients), supporting added value to HPV-only stratification. PMID:24892406

Sources

  • TCIA collection: Head-Neck-PET-CT — https://www.cancerimagingarchive.net/collection/head-neck-pet-ct/
  • PMID:24892406 — Aerts et al. 2014, Nature Communications, DOI 10.1038/ncomms5006.

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