Amoxicillin

Overview

Amoxicillin is a broad-spectrum aminopenicillin antibiotic. It is cited among antibiotic-based microbiota-modulation strategies being evaluated in the context of hepatobiliary disease, including cholangiocarcinoma (CHOL), where gut dysbiosis and LPS-driven TLR4 signaling contribute to disease progression.

Evidence in the corpus

• Cited among antibiotic-based microbiota-modulation strategies for cholangiocarcinoma adjuvant therapy targeting gut-liver axis dysbiosis; authors note that prolonged broad-spectrum antibiotic use correlates with reduced survival in HCC patients on anti-PD-1 therapy, requiring careful clinical sequencing with probiotics/FMT PMID:25608663

Resistance mechanisms

Cancer types (linked)

• CHOL — cholangiocarcinoma

Sources

• PMID:25608663

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