bintrafusp alfa

Overview

Bintrafusp alfa (M7824) is a bifunctional fusion protein combining an anti-PD-L1 (CD274) antibody with a TGF-β receptor II extracellular domain that acts as a TGF-β trap, simultaneously blocking both immunosuppressive pathways.

Evidence in the corpus

  • Bintrafusp alfa monotherapy in R/M NPC (NCT04396886, n=38): ORR 23.7%; median OS 17.0 mo; median PFS 2.3 mo; concerning safety including bleeding, anemia, and hyper-progression in platinum-refractory patients; grade ≥3 TRAE 42.4% PMID:24952746.

Resistance mechanisms

  • Hyper-progression observed in platinum-refractory R/M NPC patients, raising questions about PD-L1×TGF-β bispecific use in this population PMID:24952746.

Cancer types (linked)

Sources

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