bleomycin
Overview
Bleomycin is a cytotoxic glycopeptide antibiotic that causes single- and double-strand DNA breaks through a metal-ion-dependent oxidative mechanism. It is a component of the BEP regimen (bleomycin + etoposide + cisplatin), which is standard first-line therapy for advanced germ cell tumors. A serious toxicity is bleomycin-induced pulmonary fibrosis, which limits cumulative dosing.
Evidence in the corpus
- Component of BEP (bleomycin+etoposide+cisplatin) first-line regimen administered to 37.2% of 180 advanced GCT patients in cisplatin-resistance biomarker study; TP53 alterations were exclusive to cisplatin-resistant tumors (16.3% vs 0%; P<.001) regardless of first-line regimen type PMID:27646943
Resistance mechanisms
Cancer types (linked)
Sources
This page was processed by crosslinker on 2026-05-14.