idarubicin

Overview

Idarubicin is an anthracycline antibiotic that inhibits topoisomerase II and intercalates into DNA, causing DNA strand breakage. It is one of the most active single agents in AML and is commonly used as the anthracycline component of induction regimens. Its lipophilicity confers superior CNS penetration compared with doxorubicin.

Evidence in the corpus

• Used as the anthracycline component of ICE induction chemotherapy (idarubicin+cytarabine+etoposide) in three AMLSG intensive-therapy trials in 1540 adults with AML; study established 11 mutually exclusive genomic AML subgroups with distinct prognoses PMID:27276561

Resistance mechanisms

Cancer types (linked)

• AML

Sources

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