melphalan
Overview
Melphalan (L-phenylalanine mustard) is a bifunctional alkylating agent that cross-links DNA. It is used in high-dose autologous stem-cell transplant conditioning (principally in multiple myeloma) and has been evaluated in reduced-intensity allogeneic conditioning regimens for AML and MDS.
Evidence in the corpus
- Referenced as a component of conditioning regimens for allogeneic SCT in the context of the WashU decitabine AML/MDS trial (NCT01687400, N=116); allogeneic SCT vs no SCT was the dominant Cox survival predictor (P<0.001), and benefit was not adversely affected by TP53 status PMID:27959731
Resistance mechanisms
- Not specifically reported in the corpus.
Cancer types (linked)
Sources
- PMID:27959731 — Welch et al. 2016, NEJM. WashU AML/MDS decitabine trial; melphalan referenced as SCT conditioning context; SCT was the dominant survival predictor.
This page was processed by crosslinker on 2026-05-14.