SI-B003

Overview

SI-B003 is an investigational bispecific antibody co-targeting PDCD1 (PD-1) and CTLA4. It is evaluated in nasopharyngeal carcinoma (NPC) and other solid tumors.

Evidence in the corpus

• SI-B003 bispecific PD-1×CTLA-4 antibody listed among investigational dual checkpoint blocking strategies targeting compensatory CTLA-4 upregulation in R/M NPC PMID:24952746.

Resistance mechanisms

Cancer types (linked)

• NPC

Sources

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