AJUBA

Overview

AJUBA encodes a LIM domain protein involved in cell adhesion and signaling. It has been identified as a recurrently mutated gene in cutaneous squamous cell carcinoma (cSCC), with mutations associating with aggressive clinicopathological features.

Alterations observed in the corpus

  • Mutated in 23.1% of cSCC; mutation correlated with greater depth of invasion (16.0 ± 6.4 mm vs 8.4 ± 5.6 mm, p=0.02) and with HRAS co-mutation; significant by all four driver-detection methods PMID:25303977
  • Previously unreported somatic mutations and deletions in 6% of HNSCC (279 tumors); primarily 5’-inactivating events plus clustered missense in the LIM domain; regulates Hippo/Wnt/beta-catenin signaling; convergent with FAT1/NOTCH1 on beta-catenin pathway PMID:25631445

Cancer types (linked)

  • CSCC: 23.1% mutation frequency; associated with deeper invasion and HRAS co-mutation in aggressive cutaneous squamous cell carcinoma PMID:25303977

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic targeting reported; HRAS co-mutation context may be relevant for RAS-pathway inhibitor strategies PMID:25303977

Open questions

  • Functional mechanism of AJUBA loss-of-function in promoting tumor invasion is not established in cSCC PMID:25303977

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:25631445

This page was processed by crosslinker on 2026-05-14.