AKAP9
Overview
AKAP9 (A-Kinase Anchoring Protein 9) encodes a scaffolding protein that organizes cAMP-dependent protein kinase (PKA) signaling complexes. In cancer genomics, AKAP9 has been observed as a somatically mutated gene in gastric cancer, particularly in the context of clonal tumor evolution studies.
Alterations observed in the corpus
- Mutation/amplification identified in Pt2 of a multi-region WGS gastric cancer case study; associated with SETBP1 p.S944N mutation and CDK6 amplification in the same tumor; SETBP1 mutation matches the recurrent myeloid-malignancy site PMID:25583476
Cancer types (linked)
- Gastric cancer (STAD): Observed as an alteration in an individual tumor with complex clonal architecture in a 294-patient WES cohort from Tianjin, China PMID:25583476
Co-occurrence and mutual exclusivity
- Co-occurs with SETBP1 p.S944N and CDK6 amplification in a gastric cancer patient (Pt2) with multi-region sampling PMID:25583476
Therapeutic relevance
- No direct therapeutic targeting reported in the corpus; the CDK6 co-alteration in the same patient prompted authors to propose combined AURKC and CDK6 inhibitor therapy PMID:25583476
Open questions
- Functional impact of observed AKAP9 mutations in gastric cancer has not been validated.
- Broader prevalence across larger gastric cancer cohorts is not established from the corpus.
Sources
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