APOB
Overview
APOB encodes apolipoprotein B, the primary apolipoprotein of LDL and chylomicrons, produced in the liver. Somatic mutations in APOB are observed in HCC, likely as a passenger event reflecting the hepatocyte origin of these tumors.
Alterations observed in the corpus
- Somatic mutation reported in the HCC molecular landscape (WES, n=1,289 patients); classified as a non-actionable alteration in the comprehensive review of HCC molecular therapies PMID:24798001
- Recurrently mutated hepatocyte-secreted protein gene in HCC; part of a newly highlighted hepatic-differentiation pathway altered in 34% of 243 HCC tumors PMID:25822088
Cancer types (linked)
- HCC: Recurrent somatic mutation; not currently considered actionable PMID:24798001
Co-occurrence and mutual exclusivity
No data in current corpus.
Therapeutic relevance
Not a current therapeutic target.
Open questions
No conflicts in current corpus.
Sources
This page was processed by crosslinker on 2026-05-14. - PMID:25822088
This page was processed by crosslinker on 2026-05-14.