ATF1
Overview
ATF1 (Activating Transcription Factor 1) is a member of the CREB/ATF family of basic leucine zipper transcription factors. In cancer genomics, ATF1 is most notable as a fusion partner with EWSR1, forming the EWSR1-ATF1 fusion oncoprotein characteristic of clear cell sarcoma and related tumors. The EWSR1-ATF1 fusion disrupts normal transcriptional programs and has diagnostic and therapeutic implications in rare malignancies.
Alterations observed in the corpus
- EWSR1-ATF1 fusion identified in a clear cell odontogenic carcinoma (CCOC); novel finding in odontogenic tumors enabling histologic reclassification PMID:27442865
Cancer types (linked)
- Clear cell odontogenic carcinoma (CCOC): EWSR1-ATF1 fusion reported as a novel finding enabling tumor reclassification PMID:27442865
Co-occurrence and mutual exclusivity
- EWSR1 is the canonical fusion partner; EWSR1-ATF1 fusions are diagnostically definitive in clear cell sarcoma and related entities PMID:27442865
Therapeutic relevance
- EWSR1-ATF1 fusion in clear cell odontogenic carcinoma nominated as a diagnostic and potentially therapeutic target; analogous fusions in clear cell sarcoma may respond to targeted approaches under investigation PMID:27442865
Open questions
- Whether EWSR1-ATF1 fusions in odontogenic tumors share therapeutic vulnerabilities with clear cell sarcoma EWSR1-ATF1 fusions remains to be established.
Sources
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