BCL11B

Overview

BCL11B (B-cell CLL/lymphoma 11B) is a transcription factor with roles in T-cell development and neural differentiation. In cancer genomics it has emerged as a candidate marker in Ewing sarcoma, where its expression is linked to the neural/endothelial features of the disease.

Alterations observed in the corpus

• Newly nominated Ewing sarcoma-specific marker from spatial transcriptomics of experimental EWS::FLI1-driven tumors; previously linked to neural/endothelial features of Ewing; proposed as a discriminating biomarker (DepMap overexpression, positive IHC in experimental tumors, negative in normal thymus, spleen, and liver) PMID:25186949

Cancer types (linked)

• Ewing sarcoma: candidate marker induced in the EWS::FLI1 cell-of-origin model PMID:25186949

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:25186949

This page was processed by entity-page-writer on 2026-05-11.