BCL6

Overview

BCL6 is a transcriptional repressor and proto-oncogene that plays a central role in germinal center B-cell development. BCL6 translocations to immunoglobulin loci are a defining feature of the BN2 (BCL6/NOTCH2) molecular subtype of diffuse large B-cell lymphoma (DLBCL) in the LymphGen classification system.

Alterations observed in the corpus

  • BCL6 translocation enriched in the BN2 DLBCL subtype (77% of BN2 cases) in a real-world LymphGen classification validation study using a 400-gene clinical NGS panel (MSK-IMPACT Heme) in 241 DLBCL patients PMID:38497151.
  • BCL6 translocation co-occurs with MYC translocation in 15.3% of BN2 cases PMID:38497151.
  • IGH-BCL6 translocation in 2/11 FISH-screened PCNSL cases; recurrent 3q27 gains with breakpoints suggesting translocation PMID:25991819
  • BCL6 identified as an epigenetic regulator mutated in the advanced thyroid cancer cohort (n=117 PDTC/ATC); reported alongside CREBBP, EP300, and BCOR as low-frequency epigenetic regulator alterations PMID:26878173
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Cancer types (linked)

  • DLBCLNOS — BCL6 translocation is the cardinal classifier for the BN2 molecular subtype in the LymphGen algorithm; detected by clinical targeted NGS PMID:38497151.

Co-occurrence and mutual exclusivity

  • Co-occurs with MYC translocation in 15.3% of BN2 DLBCL cases, generating a double-hit BCL6/MYC subclass PMID:38497151.

Therapeutic relevance

  • BN2 (BCL6-translocation-enriched) DLBCL classification using targeted NGS may identify patients eligible for BCL6-directed therapies or clinical trials; molecular subtype classification can be reliably performed with a 400-gene panel at 96% accuracy for high-confidence Core classifications PMID:38497151.

Open questions

  • Whether BCL6-translocated BN2 DLBCL has a distinct prognosis from other subtypes was not statistically confirmed in this real-world cohort due to limited follow-up and cohort heterogeneity PMID:38497151.

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:25991819

This page was processed by crosslinker on 2026-05-14. - PMID:26878173

This page was processed by entity-page-writer on 2026-05-15. - PMID:28985567

This page was processed by wiki-cli on 2026-05-15.