BCLAF1
Overview
BCLAF1 (BCL2-Associated Transcription Factor 1) encodes a nuclear protein involved in transcriptional repression and apoptosis regulation. In pancreatic cancer genomics, BCLAF1 was identified as both a DNA double-strand-break / Fanconi-anaemia pathway component and a MutSigCV-significant gene in PDA whole-exome sequencing, placing it in DNA-repair pathway alterations that nominate PARP inhibition.
Alterations observed in the corpus
- DNA double-strand-break and Fanconi-anaemia pathway lesion enriched in high-CNV PDA clusters; also MutSigCV-significant; both findings nominate olaparib (PARP inhibitor) and cross-linking agents as therapeutic candidates PMID:25855536
Cancer types (linked)
- PAAD — recurrently mutated; identified in both DNA-repair pathway context and as an additional MutSigCV-significant gene PMID:25855536
Co-occurrence and mutual exclusivity
- Co-occurs with ATM, CHEK2, BRCA1, BRCA2, and Fanconi-anaemia pathway genes in high-CNV PDA PMID:25855536
Therapeutic relevance
- Part of the DNA-repair deficiency cluster that nominates olaparib and mitomycin-C in PDA PMID:25855536
Open questions
- Specific functional role of BCLAF1 within the Fanconi-anaemia pathway in PDA requires validation.
Sources
This page was processed by crosslinker on 2026-05-14.