BMPR1A
Overview
BMPR1A encodes bone morphogenetic protein receptor type 1A, a serine/threonine kinase receptor in the TGF-β superfamily signaling pathway. Germline loss-of-function variants cause juvenile polyposis syndrome (JPS), which confers elevated risk of gastrointestinal cancers including gastric cancer.
Alterations observed in the corpus
- Germline BMPR1A loss-of-function defines juvenile polyposis syndrome; included in the standard multigene panel for hereditary/familial gastric cancer (FNHGC) risk assessment — must be excluded before FNHGC labeling PMID:24816255
Cancer types (linked)
- STAD: Juvenile polyposis (BMPR1A germline) confers elevated gastric cancer risk; BMPR1A is part of the recommended GC multigene panel PMID:24816255
Co-occurrence and mutual exclusivity
No data in current corpus.
Therapeutic relevance
Not a direct therapeutic target in current corpus.
Open questions
No conflicts in current corpus.
Sources
This page was processed by entity-page-writer on 2026-05-11.