BRD2

Overview

BRD2 (Bromodomain Containing 2) is a BET family bromodomain protein that reads acetylated lysines on histones and facilitates transcriptional regulation. It is part of the chromatin-remodeling machinery altered in various cancers including adenoid cystic carcinoma.

Alterations observed in the corpus

• In-frame deletion in chromatin-remodeling gene cluster in ACC exome-sequencing cohort (n=24); part of cluster collectively mutated in 12/24 cases PMID:23778141

Cancer types (linked)

• Adenoid cystic carcinoma (ACC): in-frame deletion observed PMID:23778141

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:23778141

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