BTG1
Overview
BTG1 (B-cell translocation gene 1) is an anti-proliferative protein involved in cell cycle regulation and apoptosis. It is a member of the BTG/TOB family and acts as a transcriptional co-regulator. Inactivating mutations in BTG1 have been identified in B-cell lymphomas, consistent with a tumor suppressor role in the germinal center B-cell context.
Alterations observed in the corpus
- Nonsense and missense mutations identified as recurrent alterations in DLBCL and FL by whole-genome/exome sequencing of non-Hodgkin lymphomas; implicated in apoptosis regulation PMID:21796119
- Identified as a recurrently mutated gene in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing of 55 tumors PMID:22343534
- placeholder
Cancer types (linked)
- DLBCL / FL: Recurrent loss-of-function mutations detected alongside other recurrently mutated genes including KMT2D, CREBBP, and TP53 PMID:21796119
Co-occurrence and mutual exclusivity
- Co-mutated with other apoptosis and cell-cycle regulators (TP53, BCL2) in lymphoma; specific mutual exclusivity patterns not yet established in the corpus.
Therapeutic relevance
- No direct therapeutic targeting established; loss of BTG1 may contribute to chemotherapy resistance by impairing apoptotic response.
Open questions
- Frequency of BTG1 mutations in GCB vs ABC DLBCL subtypes, and whether mutations are biallelic, remain open questions.
Sources
This page was processed by entity-page-writer on 2026-05-06. - PMID:22343534
This page was processed by wiki-cli on 2026-05-06. - PMID:28985567
This page was processed by wiki-cli on 2026-05-15.