C2CD4C
Overview
C2CD4C (C2 calcium-dependent domain containing 4C) is a poorly characterized gene. In non-clear-cell renal cell carcinoma genomics, it was identified as significantly mutated in renal oncocytoma, a subtype with very low overall mutation rates.
Alterations observed in the corpus
- Significantly mutated in renal oncocytoma (low overall mutation rate cohort); oncogenic vs passenger status unestablished; requires larger cohorts and functional follow-up PMID:25401301
Cancer types (linked)
- ROCY: C2CD4C is one of two significantly mutated genes (alongside ERCC2) in renal oncocytoma identified by multi-method driver analysis PMID:25401301
Co-occurrence and mutual exclusivity
- Co-occurs with ERCC2 mutations as the predominant significantly mutated genes in renal oncocytoma PMID:25401301
Therapeutic relevance
- No therapeutic relevance established; functional role in renal oncocytoma tumorigenesis is unknown PMID:25401301
Open questions
- Whether C2CD4C mutations are drivers or passengers in renal oncocytoma is unestablished; authors call for larger cohorts and functional characterization PMID:25401301
Sources
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