CCDC74A
Overview
CCDC74A (Coiled-Coil Domain Containing 74A), previously reported in the literature under the alias KIAA1551, was identified as a significantly mutated gene in African American colorectal cancers, suggesting an ethnicity-associated role in CRC.
Alterations observed in the corpus
- Identified as a significantly mutated gene (reported as KIAA1551 in the original paper) in African American colorectal cancers in both discovery and validation cohorts (103 AA vs. 129 Caucasian CRC samples); part of the 20-gene panel preferentially mutated in AA CRCs PMID:25583493
Cancer types (linked)
- Colorectal cancer: identified in a significantly mutated gene panel enriched in African American CRC patients PMID:25583493
Co-occurrence and mutual exclusivity
Therapeutic relevance
Open questions
- Functional significance of CCDC74A mutations in AA CRC has not been experimentally validated PMID:25583493
Sources
This page was processed by entity-page-writer on 2026-05-14.