CCNB1

Overview

CCNB1 (Cyclin B1) encodes a regulatory protein that controls cell cycle progression at the G2/M checkpoint. Elevated CCNB1 expression is associated with aggressive tumor phenotypes and is frequently observed in genomically unstable cancers.

Alterations observed in the corpus

  • High RPPA protein expression in POLE-ultramutated and cell-cycle-deregulated endometrial carcinoma subgroups PMID:23636398

Cancer types (linked)

  • Endometrial carcinoma: elevated RPPA expression in POLE-ultramutated subgroup PMID:23636398

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • No direct therapeutic data in the corpus.

Open questions

  • Whether CCNB1 overexpression is a driver or passenger event in POLE-ultramutated tumors remains unclear.

Sources

This page was processed by crosslinker on 2026-05-09.