CD44

Overview

CD44 is a cell-surface glycoprotein and canonical cancer stem cell (CSC) marker involved in cell adhesion, migration, and signaling. It is frequently overexpressed or amplified in multiple cancer types and serves as a readout of EMT and stem-like cell state.

Alterations observed in the corpus

• EMT/stemness marker upregulated in GBC cells (GBC-SD, NOZ) in response to paracrine SEMA7A from stiff-matrix-activated cancer-associated fibroblasts; elevated in co-injection xenografts, downregulated by SEMA7A knockdown in GFs PMID:24997986
• Focal amplification in the CIN subtype of gastric adenocarcinoma; included among recurrent CIN copy-number gains PMID:25079317
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Cancer types (linked)

• GBC: CD44 upregulation downstream of the SEMA7A/ITGB1/AKT1/EP300 signaling axis reflects acquisition of stem-like traits in GBC cells PMID:24997986
• STAD: focal amplification in CIN subtype PMID:25079317

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:24997986
• PMID:25079317

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