CD70

Overview

CD70 (TNF superfamily member 7, TNFSF7) is the ligand for CD27 and is transiently expressed on activated lymphocytes and dendritic cells. In tumors, CD70 expression sustains regulatory T cell (Treg) survival via CD27 signaling, contributing to immune evasion. CD70 is a therapeutic target in hematologic malignancies and solid tumors via ADCs and CAR-T cells.

Alterations observed in the corpus

• CD70 (TNF ligand) engages CD27 to sustain Treg survival in NPC TME; targeted by ADCs GEN1160 and CAR-T CHT101 PMID:24952746
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Cancer types (linked)

• NPC: CD70 promotes Treg survival; anti-CD70 ADC GEN1160 and CAR-T CHT101 under investigation PMID:24952746

Co-occurrence and mutual exclusivity

No data in current corpus.

Therapeutic relevance

• GEN1160 (anti-CD70 ADC) — investigational in NPC PMID:24952746
• CHT101 (anti-CD70 CAR-T) — investigational in NPC PMID:24952746

Open questions

No conflicts in current corpus.

Sources

• PMID:24952746

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