CD79B

Overview

CD79B encodes the Ig-beta component of the B-cell receptor. ITAM-domain mutations (notably Y196) drive chronic active BCR signaling and are recurrent in activated B-cell DLBCL and primary CNS lymphoma.

Alterations observed in the corpus

  • Mutated in 48% of PCNSLs profiled with MSK-HemePACT in the MSK ibrutinib phase II trial PMID:38995739.
  • Mutations serve as a key classifier for the MCD subtype in the LymphGen molecular classification algorithm, alongside MYD88 mutations; detectable by targeted 400-gene clinical NGS panels (e.g., MSK-IMPACT Heme) with high fidelity PMID:38497151.
  • Identified as recurrently mutated in DLBCL and FL by whole-genome/exome sequencing of non-Hodgkin lymphomas PMID:21796119
  • Identified as a recurrently mutated gene in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing of 55 tumors PMID:22343534
  • Activating mutations in 40% of PCNSL cases; frequently co-occur with MYD88 L265P mutations (3 of 4 CD79B-mutant cases); higher prevalence than nodal DLBCL PMID:25991819
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Cancer types (linked)

  • PCNSL — canonical BCR-pathway driver; part of the non-germinal-center (Hans classifier) profile that dominated the MSK ibrutinib cohort (21/25, 84%) PMID:38995739.
  • DLBCLNOS — established ABC-subtype driver PMID:38995739; CD79B mutations define the MCD subtype in conjunction with MYD88 mutations; validated by LymphGen classification on a real-world clinical NGS panel PMID:38497151.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • CD79B mutations drive BCR-pathway dependence, the rationale for ibrutinib treatment in PCNSL; the MSK phase II trial did not report an independent PFS association for CD79B status PMID:38995739.

Open questions

Sources

This page was processed by crosslinker on 2026-05-14. - PMID:21796119

This page was processed by crosslinker on 2026-05-14. - PMID:22343534

This page was processed by crosslinker on 2026-05-14. - PMID:25991819

This page was processed by crosslinker on 2026-05-14. - PMID:28985567

This page was processed by wiki-cli on 2026-05-15.