CDK2

Overview

CDK2 (Cyclin-Dependent Kinase 2) is a serine/threonine kinase that regulates cell cycle progression through G1/S and S phase. CDK2 was assessed as a DDR candidate in synthetic lethal screening in colorectal cancer.

Alterations observed in the corpus

• Screened as a DDR candidate in FBXO7 synthetic lethality study; not prioritized as a primary SL target PMID:36334560
• CDK2 gain at 12q14.1 in glioblastoma multiforme; classified as a CDK4/6-inhibitor target in the PIPseq pediatric precision-oncology cohort PMID:28007021

Cancer types (linked)

• CRC: assessed as potential SL target in FBXO7-deficient tumors PMID:36334560

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:36334560

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