CHFR
Overview
CHFR (Checkpoint with Forkhead and Ring Finger Domains) is an E3 ubiquitin ligase that functions as a mitotic stress checkpoint protein. Epigenetic silencing of CHFR via promoter hypermethylation has been documented in multiple cancers and has been associated with sensitivity to microtubule-stabilizing agents such as taxanes.
Alterations observed in the corpus
- CHFR epigenetic silencing (promoter hypermethylation) enriched in the proximal hypermethylated GEA-CIN cluster 1 in the TCGA multi-platform esophageal carcinoma study; raises the prospect of differential microtubule-inhibitor response based on prior literature PMID:28052061
Cancer types (linked)
- ESCC / ESCA: CHFR silencing enriched in proximal GEA-CIN hypermethylated cluster; prior literature links CHFR silencing to taxane sensitivity PMID:28052061
Co-occurrence and mutual exclusivity
- CHFR silencing co-occurs with MGMT silencing in the proximal hypermethylated GEA-CIN cluster 1 PMID:28052061
Therapeutic relevance
- CHFR silencing has been linked in prior literature to sensitivity to microtubule inhibitors (taxanes); this association is hypothesis-generating in the context of esophageal/GEA-CIN cancers and has not been prospectively validated PMID:28052061
Open questions
- Prospective biomarker validation of CHFR silencing as a predictor of taxane response in esophageal/gastroesophageal junction cancers is lacking PMID:28052061
Sources
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