CHGB

Overview

CHGB (chromogranin B, also known as secretogranin I) is a neuroendocrine secretory protein of the granin family. In neuroblastoma single-cell transcriptomics, CHGB is part of the noradrenergic/adrenergic gene panel marking noradrenergic tumor clusters and postnatal chromaffin cells in normal adrenal gland.

Alterations observed in the corpus

  • CHGB is part of the noradrenergic/adrenergic panel alongside PHOX2B, PHOX2A, TH, DBH, CHGA, PNMT, and ISL1; these genes mark the NOR (noradrenergic) tumor clusters and postnatal chromaffin cells identified by single-nuclei RNA-seq of 11 neuroblastoma tumors PMID:34493726.

Cancer types (linked)

  • Neuroblastoma (NBL) — CHGB marks the noradrenergic/adrenergic low-risk tumor clusters (nC5/nC7/nC8/nC9) that are enriched in low-risk disease; expression is characteristic of adrenergic/chromaffin differentiation PMID:34493726.

Co-occurrence and mutual exclusivity

Therapeutic relevance

  • CHGB-positive noradrenergic tumor cells characterize low-risk neuroblastoma; their expression profile is associated with favorable prognosis through adrenergic differentiation PMID:34493726.

Open questions

  • The role of CHGB protein secretion in neuroblastoma tumor microenvironment biology is not addressed in the corpus.

Sources

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