CLCN6

Overview

CLCN6 (Chloride Voltage-Gated Channel 6) encodes a voltage-gated chloride channel. In cancer genomics, it has been identified as a novel 5’ fusion partner for BRAF in pilocytic astrocytoma.

Alterations observed in the corpus

• Novel 5’ fusion partner for BRAF in pilocytic astrocytoma (WGS cohort n=96); functional dissection of this specific BRAF fusion partner not reported PMID:23817572

Cancer types (linked)

• Pilocytic astrocytoma: identified as novel BRAF 5’ fusion partner PMID:23817572

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

• Functional consequence of CLCN6:BRAF fusion has not been characterized PMID:23817572

Sources

• PMID:23817572

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