COL1A2

Overview

COL1A2 encodes the pro-alpha2 chain of type I collagen, a major structural component of the extracellular matrix. In cancer, COL1A2 is a marker of desmoplastic stroma and CAF activation.

Alterations observed in the corpus

• Expression positively correlated with stromal SEMA7A in GBC tissues, implicating it in the desmoplastic CAF activation program driven by matrix stiffness PMID:24997986

Cancer types (linked)

• GBC: COL1A2 co-expressed with SEMA7A in the desmoplastic stroma of gallbladder cancer; part of the fibrillar collagen signature of activated CAFs PMID:24997986

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:24997986

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