COL4A2

Overview

COL4A2 encodes the alpha2 chain of type IV collagen. It is a structural basement membrane component and marker of desmoplastic stroma in cancer.

Alterations observed in the corpus

• Expression positively correlated with stromal SEMA7A in GBC tissues, part of the fibrillar collagen signature associated with desmoplastic stroma and CAF activation PMID:24997986

Cancer types (linked)

• GBC: COL4A2 co-expressed with SEMA7A in the desmoplastic stroma of gallbladder cancer PMID:24997986

Co-occurrence and mutual exclusivity

Therapeutic relevance

Open questions

Sources

• PMID:24997986

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