COL6A3
Overview
COL6A3 (Collagen Type VI Alpha 3 Chain) encodes the alpha-3 chain of type VI collagen, a major extracellular matrix component involved in cell adhesion and interaction with the tumor microenvironment. Somatic mutations in COL6A3 have been reported in breast and other cancer types, with potential roles in altering ECM architecture and facilitating invasion.
Alterations observed in the corpus
- Somatic mutations in 6.2% (4/65) of TNBC cases in a whole-genome sequencing study of 65 breast tumors (BCCRC cohort) PMID:22495314
Cancer types (linked)
- TNBC (triple-negative breast cancer): Recurrent somatic mutations in 6.2% of cases identified by WGS; significance as a driver versus passenger alteration not definitively established PMID:22495314
Co-occurrence and mutual exclusivity
- No specific co-occurrence or mutual exclusivity patterns reported in the current corpus.
Therapeutic relevance
- No approved agents target COL6A3 directly; its role in ECM remodeling raises questions about its contribution to the tumor microenvironment in TNBC.
Open questions
- Whether COL6A3 mutations represent driver events or passenger mutations in TNBC requires functional validation.
- The impact of COL6A3 mutations on ECM organization and tumor cell invasion in breast cancer is unclear.
Sources
This page was processed by entity-page-writer on 2026-05-06.